纳米复合水凝胶材料在损伤软骨再生中的应用及其摩擦学力学性能

IF 4.2 Q2 NANOSCIENCE & NANOTECHNOLOGY
P. Sagar, G. Kumar, A. Handa
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引用次数: 0

摘要

骨关节炎(OA)是一种非炎症性恶化的衰弱状态,在全球范围内带来了显著的健康和经济问题。关节软骨(AC)的破坏/恶化是骨关节炎(OA)的病理特征之一。纳米复合水凝胶(NCH)材料是一种潜在的器官再生和组织工程支架材料。近年来,专门装载纳米颗粒的创新水凝胶已被开发和合成,目的是改变传统的软骨治疗方法。本文介绍了用于组织工程的定制纳米复合水凝胶(NCH)材料的详细开发。此外,这些生产的NCH的机械特性,特别是摩擦学性能也得到了强调。本文综述了大量关于水凝胶物质在软骨愈合中的应用的研究和数据。在确定未来软骨再生水凝胶领域的研究空白时,这些信息将为研究人员进一步开发NCH提供优势。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Progressive use of nanocomposite hydrogels materials for regeneration of damaged cartilage and their tribological mechanical properties
Osteoarthritis (OA) is a non-inflammatory deteriorating debilitating state that bring about remarkable health and economic issues globally. Break down/deterioration of the articular cartilage (AC) is one of the pathologic characteristics of osteoarthritis (OA). Nanocomposite hydrogels (NCH) materials are evolving as a potential class of scaffolds for organ regeneration and tissue engineering. In recent years, innovative hydrogels specifically loaded with nanoparticles have been developed and synthesized with the goal of changing conventional cartilage treatments. The detailed development of a tailored nanocomposite hydrogels (NCH) material utilized for tissue engineering is presented in this review study. Also, the mechanical characteristics, particularly the tribological behavior, of these produced NCH have been highlighted. Large amounts of research and data on the hydrogel substance utilized in cartilage healing are summarized in the current review study. When determining future research gaps in the area of hydrogels for cartilage regeneration, such information will provide researchers an advantage to further develop NCH.
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来源期刊
CiteScore
6.00
自引率
1.70%
发文量
24
期刊介绍: Proceedings of the Institution of Mechanical Engineers Part N-Journal of Nanomaterials Nanoengineering and Nanosystems is a peer-reviewed scientific journal published since 2004 by SAGE Publications on behalf of the Institution of Mechanical Engineers. The journal focuses on research in the field of nanoengineering, nanoscience and nanotechnology and aims to publish high quality academic papers in this field. In addition, the journal is indexed in several reputable academic databases and abstracting services, including Scopus, Compendex, and CSA's Advanced Polymers Abstracts, Composites Industry Abstracts, and Earthquake Engineering Abstracts.
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