{"title":"抗菌喹诺酮类药物致光毒性机理研究","authors":"F. Vargas, C. Rivas","doi":"10.1080/107691897229810","DOIUrl":null,"url":null,"abstract":"Recent research on elucidation of mechanisms of the phototoxic activities of various pharmaceutical products currently being investigated in this laboratory is reviewed. Due to the importance of antibacterial quinolones of com mon use in present m edical practice, it is considered of general interest to summ arize the photochem ical reactions involved in the generation of active photoproducts and the possibility of metabolite mediation in biological damage. Thus, m echanism s are postulated for the photochemical decomposition of the substances investigated as well as the possible in vitro m echanism involved at cellular level.","PeriodicalId":87425,"journal":{"name":"Toxic substance mechanisms","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1997-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"11","resultStr":"{\"title\":\"MECHANISTIC STUDIES ON PHOTOTOXICITY INDUCED BY ANTIBACTERIAL QUINOLONES\",\"authors\":\"F. Vargas, C. Rivas\",\"doi\":\"10.1080/107691897229810\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Recent research on elucidation of mechanisms of the phototoxic activities of various pharmaceutical products currently being investigated in this laboratory is reviewed. Due to the importance of antibacterial quinolones of com mon use in present m edical practice, it is considered of general interest to summ arize the photochem ical reactions involved in the generation of active photoproducts and the possibility of metabolite mediation in biological damage. Thus, m echanism s are postulated for the photochemical decomposition of the substances investigated as well as the possible in vitro m echanism involved at cellular level.\",\"PeriodicalId\":87425,\"journal\":{\"name\":\"Toxic substance mechanisms\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1997-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"11\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Toxic substance mechanisms\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/107691897229810\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Toxic substance mechanisms","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/107691897229810","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
MECHANISTIC STUDIES ON PHOTOTOXICITY INDUCED BY ANTIBACTERIAL QUINOLONES
Recent research on elucidation of mechanisms of the phototoxic activities of various pharmaceutical products currently being investigated in this laboratory is reviewed. Due to the importance of antibacterial quinolones of com mon use in present m edical practice, it is considered of general interest to summ arize the photochem ical reactions involved in the generation of active photoproducts and the possibility of metabolite mediation in biological damage. Thus, m echanism s are postulated for the photochemical decomposition of the substances investigated as well as the possible in vitro m echanism involved at cellular level.
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