GABA和谷氨酸的功能障碍是抑郁症的途径:证据综述

C. Sharpley
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引用次数: 4

摘要

近五分之一的人在一生中会经历抑郁症,再加上最近的研究发现抑郁症与死亡率的关系堪比吸烟,因此寻找有效的药物治疗抑郁症的方法仍然迫在眉睫。然而,尽管社会承受着如此沉重的疾病负担,但在过去40年里开发的各种抗抑郁药都显示出明显的副作用,而且与安慰剂相比几乎没有特定的疗效。一种潜在的治疗方法可能是通过重新建立谷氨酸和GABA神经递质系统,这些系统在抑郁症患者中已经被证明功能失调。文献描述可能的因果关系之间的氨基丁酸和/或谷氨酸功能障碍和抑郁症的回顾,以及那些研究提供的实验数据,以证实这一假设。虽然这些神经递质功能障碍与抑郁症之间的联系似乎得到了支持,但基于这些发现开发有效的抗抑郁药物的数据却很少。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Malfunction in GABA and Glutamate as Pathways to Depression: A Review of the Evidence:
With nearly one fifth of the population experiencing depression sometime during their lives, plus the recent finding that depression rivals smoking in its association with mortality, the search for effective pharmacological treatments for depression remains urgent. However, despite this heavy disease burden upon society, the various waves of antidepressants developed in the last 40 years have shown significant side effects and little specific efficacy over placebo. One potential treatment may be via re-establishment of glutamate and GABA neurotransmitter systems that have been shown to malfunction in depressed patients. The literature describing possible causal links between GABA and/or glutamate malfunction and depression is reviewed, plus those studies which provide experimental data to confirm this hypothesis. While there is plausible support for the links between malfunction of these neurotransmitters and depression, few data exist yet regarding development of effective antidepressant medications based upon these findings.
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