{"title":"全身氧化应激:神经退行性变的关键点--综述。","authors":"E E Martínez Leo, M R Segura Campos","doi":"10.1007/s12603-019-1240-8","DOIUrl":null,"url":null,"abstract":"<p><p>Systemic oxidative stress (SOS) has an important role in the mechanisms activation of neuronal death, involved in the neurodegenerative disease (ND) etiology. Brain is susceptible to oxidative stress injuries due to its high energy and metabolic request, therefore minimal imbalances of the redox state, as occurs in mitochondrial dysfunction, favour tissue injury and neuroinflammatory mechanisms activation. ND affect around the world about a billion people, without distinction of sex, educational level and economic status. Public measures generation that prevent ND from the SOS are possible promising therapeutic targets that could reduce the ND incidence. We discuss here the effects and mechanisms of SOS derived neurodegeneration, as well as the neuroinflammation repercussions for some cerebral structures.</p>","PeriodicalId":22788,"journal":{"name":"The Journal of Nutrition Health and Aging","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Systemic Oxidative Stress: A key Point in Neurodegeneration - A Review.\",\"authors\":\"E E Martínez Leo, M R Segura Campos\",\"doi\":\"10.1007/s12603-019-1240-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Systemic oxidative stress (SOS) has an important role in the mechanisms activation of neuronal death, involved in the neurodegenerative disease (ND) etiology. Brain is susceptible to oxidative stress injuries due to its high energy and metabolic request, therefore minimal imbalances of the redox state, as occurs in mitochondrial dysfunction, favour tissue injury and neuroinflammatory mechanisms activation. ND affect around the world about a billion people, without distinction of sex, educational level and economic status. Public measures generation that prevent ND from the SOS are possible promising therapeutic targets that could reduce the ND incidence. We discuss here the effects and mechanisms of SOS derived neurodegeneration, as well as the neuroinflammation repercussions for some cerebral structures.</p>\",\"PeriodicalId\":22788,\"journal\":{\"name\":\"The Journal of Nutrition Health and Aging\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Journal of Nutrition Health and Aging\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s12603-019-1240-8\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of Nutrition Health and Aging","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s12603-019-1240-8","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
全身氧化应激(SOS)在激活神经元死亡的机制中起着重要作用,参与了神经退行性疾病(ND)的病因学研究。由于大脑需要大量能量和新陈代谢,很容易受到氧化应激的伤害,因此氧化还原状态的最小失衡(如线粒体功能障碍)有利于组织损伤和神经炎症机制的激活。全世界约有十亿人受到 ND 的影响,不分性别、教育水平和经济状况。从 SOS 开始预防 ND 的公共措施可能是有希望降低 ND 发病率的治疗目标。我们在此讨论 SOS 引起的神经变性的影响和机制,以及神经炎症对某些大脑结构的影响。
Systemic Oxidative Stress: A key Point in Neurodegeneration - A Review.
Systemic oxidative stress (SOS) has an important role in the mechanisms activation of neuronal death, involved in the neurodegenerative disease (ND) etiology. Brain is susceptible to oxidative stress injuries due to its high energy and metabolic request, therefore minimal imbalances of the redox state, as occurs in mitochondrial dysfunction, favour tissue injury and neuroinflammatory mechanisms activation. ND affect around the world about a billion people, without distinction of sex, educational level and economic status. Public measures generation that prevent ND from the SOS are possible promising therapeutic targets that could reduce the ND incidence. We discuss here the effects and mechanisms of SOS derived neurodegeneration, as well as the neuroinflammation repercussions for some cerebral structures.