细胞嵌合体小鼠胸腺淋巴瘤的单细胞起源。

Philosophia (Ramat-Gan, Israel) Pub Date : 1984-11-01 DOI:10.20772/CANCERSCI1959.75.11_1002

M. Bessho, I. Jinnai, K. Hirashima, K. Tanaka, H. Tanooka

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引用次数: 9

摘要

在磷酸甘油酸激酶(PGK)细胞嵌合的小鼠中研究了辐射诱导胸腺淋巴瘤的克隆起源。连续7天的全身x射线照射(4次剂量，每次1.7 Gy)导致马赛克小鼠胸腺淋巴瘤的发生。来自所有淋巴瘤的PGK在电泳上只有一个斑点。结果证实胸腺淋巴瘤的单细胞起源。

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Single cell origin of radiation-induced thymic lymphoma in mice with cellular mosaicism.

The clonal origin of radiation-induced thymic lymphoma was studied in mice with cellular mosaicism for phosphoglycerate kinase (PGK). Repeated whole-body X-irradiations (4 doses, 1.7 Gy each) with intervals of 7 days resulted in development of thymic lymphomas in the mosaic mice. PGK from all lymphomas gave only a single spot on electrophoresis. The results demonstrate the single cell origin of the thymic lymphoma.

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Philosophia (Ramat-Gan, Israel)

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