Box-Behnken法优化乳状液膜提取布洛芬的工艺

IF 1.2 Q3 MULTIDISCIPLINARY SCIENCES

Journal of Physical Science Pub Date : 2022-08-25 DOI:10.21315/jps2022.33.2.6

Mohd Hazarel Zairy Mohd Harun, A. Ahmad

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引用次数: 1

摘要

乳状液膜法是一种很有前途的提取布洛芬的方法。载体浓度、表面活性剂浓度和内相浓度是优化IBP萃取效率的重要参数。采用Box-Behnken设计(BBD)对ELM的主要参数Aliquat 336 (A)、Span 80 (B)和碳酸钠Na2CO3 (C)进行优化，采用二次多项式回归计算响应，结果表明该模型对实验数据集具有显著性，f值和p值分别为17.88%和0.05%。Span 80和Na2CO3相互作用对ELM提取IBP具有重要意义。在优化条件下，Aliquat 336浓度(2 wt%)、Span 80浓度(4 wt%)和Na2CO3浓度(0.1 M)的IBP提取率为96.78%。

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Optimisation of Ibuprofen Extraction by Emulsion Liquid Membrane Using Box-Behnken Design

Emulsion liquid membrane (ELM) is a potential method for extracting ibuprofen (IBP) from aqueous solution. The concentrations of the carrier, surfactant and internal phases are important parameters to optimise the extraction efficiency of IBP. The Box-Behnken design (BBD) is used to optimise the main parameters of ELM, which are Aliquat 336 (A), Span 80 (B) and sodium carbonate, Na2CO3 (C). The responses were calculated using quadratic polynomial regression and the model suggests a significant result with the experimental data set, with the F-value and p-value calculated at 17.88% and 0.05%, respectively. Span 80 and Na2CO3 had a mutual interaction which was significant for the IBP extraction by ELM. At the optimised parameters, namely Aliquat 336 concentration (2 wt%), Span 80 concentration (4 wt%) and Na2CO3 concentration (0.1 M) resulted in 96.78% of IBP extraction.

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来源期刊

Journal of Physical Science Physics and Astronomy-Physics and Astronomy (all)

CiteScore

1.70

自引率

0.00%

发文量

期刊介绍： The aim of the journal is to disseminate latest scientific ideas and findings in the field of physical sciences among scientists in Malaysia and international regions. This journal is devoted to the publication of articles dealing with research works in Chemistry, Physics and Engineering. Review articles will also be considered. Manuscripts must be of scientific value and will be submitted to independent referees for review. Contributions must be written in English and must not have been published elsewhere.