慢性髓性白血病患者的计划妊娠

P. Ault, J. Cortes
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引用次数: 5

摘要

慢性髓性白血病(CML)在怀孕期间的管理可能是困难的患者,他们的家人和医护人员。治疗慢性粒细胞白血病和妊娠仍然是一个临床挑战。目前的建议,对于有生育潜力的妇女,使用适当的避孕措施,避免怀孕,同时服用激酶抑制剂。胎儿在怀孕期间暴露于激酶抑制剂的后果尚不清楚。治疗可能导致严重胎儿畸形或自然流产的风险增加。在怀孕期间,缺乏对CML的治疗可能导致疾病进展。在缺乏详细信息的情况下,引导患者通过决策过程出现困难。希望中断治疗并怀孕的患者应该接受父母双方的密集咨询,使用最新的可用数据。关于CML患者和妊娠的决定必须基于个案。本报告描述了一名新诊断为CML的25岁女性,在开始博舒替尼化疗治疗CML之前,她有目的地安排了未受精卵子的采集和储存
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Planned Pregnancy for a Patient with Chronic Myeloid Leukemia
Management of chronic myeloid leukemia (CML) during pregnancy can be difficult for patients, their families and care providers. Treatment of CML and pregnancy remains a clinical challenge. Current recommendations, for women of childbearing potential, are to use adequate contraception and avoid pregnancy while taking kinase inhibitors. Consequences of exposure to kinase inhibitors to a fetus during pregnancy are unknown. Treatment may result in an increased risk of serious fetal abnormalities or spontaneous abortion. Lack of treatment for CML, during a pregnancy, may result in disease progression. In the absence of detailed information, difficulty arises to guide this patient through a decision making process. Patients who wish to interrupt therapy and become pregnant should receive intense counseling for both parents, using the most recent data available. Decisions concerning patients with CML and pregnancies must be based on individual cases. This report describes a 25 year old woman with newly diagnosed CML who purposefully arranged harvesting and storage of her unfertilized ova, prior to commencing bosutinib chemotherapy for CML
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