临床确诊寻常型银屑病的组织病理学评价

Sawitri, Arisia Fadila, M. Yulianto Listiawan, Priangga Adi Wiratama, Dwi Murtiastutik, Evy Ervianti, Linda Astari, Damayanti, Diah Mira Indramaya, Afif Nurul Hidayati, Medhi Denisa Alinda
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引用次数: 0

摘要

背景:寻常型银屑病可以临床诊断。活检通常用于确认非典型病例。组织病理学特征的发现通常不存在,因此需要临床相关性来确认诊断。目的:描述Soetomo总医院病理解剖科报告的经组织病理学证实的寻常型牛皮癣组织标本的组织病理学结果。方法:对在Dr. Soetomo综合学术医院皮肤科和性病门诊2年时间内病理解剖科病理确诊的寻常型银屑病组织样本进行描述性回顾性研究。组织病理学切片用苏木精和伊红染色后观察形态学参数。结果:共检查组织标本33份。角化不全(86%)和少颗粒(70.3%)是最常见的表现。棒状网脊、乳头上板变薄和海绵状脓疱是最少观察到的发现(各为2.7%)。3个组织样本(8.1%)仅显示角化不全。仅有1份(2.7%)组织标本表现出4种特征(无颗粒层、角化不全、Munro型微脓肿、Kogoj型海绵状脓疱)。没有组织样本显示寻常型银屑病的所有组织病理学发现。结论:寻常型银屑病的所有组织病理特征在一个组织切片上很少发现。尽管组织病理学被认为是寻常型银屑病的金标准诊断,但与临床结果的相关性仍然是支持诊断的强制性要求。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of Histopathology Findings of Clinically Confirmed Psoriasis Vulgaris
Background: Psoriasis vulgaris can be diagnosed clinically. A biopsy is usually used to confirm non-classic cases. The findings of the histopathology feature are not usually present, thus clinical relevance is needed to confirm the diagnosis. Purpose: To describe the histopathology findings from tissue samples of histopathologically confirmed psoriasis vulgaris reported in the Department of Pathology and Anatomy of Dr. Soetomo General Hospital. Methods: A descriptive-retrospective study of pathology-ascertained tissue samples of histopathologically confirmed psoriasis vulgaris was reported in the Department of Pathology and Anatomy from patients who were also previously diagnosed clinically with psoriasis vulgaris in the Dermatology and Venereology Outpatient Unit of Dr. Soetomo General Academic Hospital over a period of 2 years. Morphological parameters were observed after histopathology sections were stained with hematoxylin and eosin. Result: Thirty-three tissue samples were examined. Parakeratosis (86%) and hypogranulosis (70.3%) were the most observed findings. Club-shaped rete ridges, suprapapillary plate thinning, and spongiform pustules of Kogoj were the least observed findings (each by 2.7%). Three tissue samples (8.1%) showed only parakeratosis. Only 1 tissue sample (2.7%) showed 4 features (absence of the granular layer, parakeratosis, microabscess of Munro, and spongiform pustules of Kogoj). No tissue sample showed every histopathology finding of psoriasis vulgaris. Conclusion: All of the histopathology features of psoriasis vulgaris are rarely found in one tissue section. Albeit histopathology is believed to be the gold standard diagnosis of psoriasis vulgaris, relevance with clinical findings is still mandatory to support the diagnosis.
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