心菖蒲体外抗癌潜力的研究

Md. Nasar Mallick, W. Khan, Mhaveer Singh, Mohd. Zeeshan Najm, M. Kashif, Sayeed Ahmad, S. Husain
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引用次数: 5

摘要

背景:考虑到半仙人掌的毒性。根据传统文献的报道,本研究对半仙人掌乙醇提取物对两种不同细胞系的体外细胞毒活性进行了研究。材料与方法:采用冷浸法制备半山竹醇提物。采用3-(4,5-二甲基噻唑-2-基)-2,5-二苯基溴化四唑乙醇提取物对HeLa和SiHa细胞株进行细胞毒性测定。结果:心梗草醇提物对HeLa和SiHa细胞株的ic50值分别为44.0和57.0 μg/ml。采用薄层色谱、气相色谱-质谱联用技术对提取液进行标准化。结论:心梗草醇提物对两种细胞系均有良好的细胞毒活性,可能是由于其含有毒性黄酮所致。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
In vitro anticancer potential of Semecarpus anacardium Linn
Background: Keeping in view the toxicity of Semecarpus anacardium Linn. as reported in the traditional literature, the present study was carried out to evaluate the in vitro cytotoxic activity of ethanolic extract of Semecarpus on two different cell lines. Materials and Methods: The ethanolic extract of Semecarpus was prepared using cold extraction method. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay of ethanolic extract was carried out on HeLa and SiHa cell lines for determination of cytotoxicity. Results: The IC50values of ethanolic extract of S. anacardium in HeLa and SiHa cell lines were 44.0 μg/ml and 57.0 μg/ml, respectively. The extract was standardized by thin-layer chromatography and Gas chromatography-mass spectrometry. Conclusion: The results showed good cytotoxic activity in the ethanolic extract of S. anacardium in both the cell lines may be due to the presence of toxic flavones.
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