{"title":"汉鼻草多态性衍生聚乙二醇干扰素-α2a的三维结构研究","authors":"F. Mueller","doi":"10.1016/S1594-5804(09)60009-7","DOIUrl":null,"url":null,"abstract":"<div><p>The majority of interferons available for therapeutic use are derived from the prokaryote <em>E. coli</em>. A new recombinant human interferon α2a (IFN-α2a; Reiferon®) has been derived from the yeast <em>Hansenula polymorpha</em> – a eukaryotic expression system. Safety and efficacy for this drug was tested in patients with chronic hepatitis C in Egypt. The unmodified yeast-derived IFN-α2a is the basis for a newly developed PEGylated IFN-α2a (Reiferon Retard®) which will be described in the following.</p></div>","PeriodicalId":100375,"journal":{"name":"Digestive and Liver Disease Supplements","volume":"3 1","pages":"Pages 9-12"},"PeriodicalIF":0.0000,"publicationDate":"2009-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1594-5804(09)60009-7","citationCount":"1","resultStr":"{\"title\":\"3-D structural approach on the Hansenula polymorpha-derived PEGylated interferon-α2a\",\"authors\":\"F. Mueller\",\"doi\":\"10.1016/S1594-5804(09)60009-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The majority of interferons available for therapeutic use are derived from the prokaryote <em>E. coli</em>. A new recombinant human interferon α2a (IFN-α2a; Reiferon®) has been derived from the yeast <em>Hansenula polymorpha</em> – a eukaryotic expression system. Safety and efficacy for this drug was tested in patients with chronic hepatitis C in Egypt. The unmodified yeast-derived IFN-α2a is the basis for a newly developed PEGylated IFN-α2a (Reiferon Retard®) which will be described in the following.</p></div>\",\"PeriodicalId\":100375,\"journal\":{\"name\":\"Digestive and Liver Disease Supplements\",\"volume\":\"3 1\",\"pages\":\"Pages 9-12\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2009-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S1594-5804(09)60009-7\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Digestive and Liver Disease Supplements\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1594580409600097\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Digestive and Liver Disease Supplements","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1594580409600097","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
3-D structural approach on the Hansenula polymorpha-derived PEGylated interferon-α2a
The majority of interferons available for therapeutic use are derived from the prokaryote E. coli. A new recombinant human interferon α2a (IFN-α2a; Reiferon®) has been derived from the yeast Hansenula polymorpha – a eukaryotic expression system. Safety and efficacy for this drug was tested in patients with chronic hepatitis C in Egypt. The unmodified yeast-derived IFN-α2a is the basis for a newly developed PEGylated IFN-α2a (Reiferon Retard®) which will be described in the following.
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