艾滋病毒疫苗目标和策略的合理设计:统计物理学、生物学和医学的十字路口

IF 19 1区物理与天体物理 Q1 PHYSICS, MULTIDISCIPLINARY

Reports on Progress in Physics Pub Date : 2017-02-13 DOI:10.1088/1361-6633/aa574a

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引用次数: 20

摘要

接种疫苗挽救的生命比任何其他医疗程序都要多。病原体现在已经进化到不屈服于使用巴斯德和詹纳开创的经验范例的疫苗接种。需要基于对相关免疫学和病毒学的机制理解的疫苗设计策略来面对和消除这些祸害。从这个角度来看，我们只描述了几个工作的例子，这些工作旨在通过将统计物理学与生物学和临床研究相结合的方法来实现这一目标。

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Rational design of vaccine targets and strategies for HIV: a crossroad of statistical physics, biology, and medicine

Vaccination has saved more lives than any other medical procedure. Pathogens have now evolved that have not succumbed to vaccination using the empirical paradigms pioneered by Pasteur and Jenner. Vaccine design strategies that are based on a mechanistic understanding of the pertinent immunology and virology are required to confront and eliminate these scourges. In this perspective, we describe just a few examples of work aimed to achieve this goal by bringing together approaches from statistical physics with biology and clinical research.

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来源期刊

Reports on Progress in Physics 物理-物理：综合

CiteScore

31.90

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Reports on Progress in Physics is a highly selective journal with a mission to publish ground-breaking new research and authoritative invited reviews of the highest quality and significance across all areas of physics and related areas. Articles must be essential reading for specialists, and likely to be of broader multidisciplinary interest with the expectation for long-term scientific impact and influence on the current state and/or future direction of a field.