拉帕替尼对晚期实体瘤患者健康相关生活质量影响的综述

J. Price, Q. Chu
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引用次数: 0

摘要

拉帕替尼是一种口服表皮生长因子受体(HER1/ErbB1/EGFR)和人表皮生长因子受体2 (HER2/ErbB2)的双重抑制剂,于2007年被批准用于转移性乳腺癌患者。在这篇综述中,我们讨论了拉帕替尼临床试验患者的生活质量(QOL)结果。6项临床试验,包括4项III期试验和2项II期试验,已报告了生活质量结果。这些试验普遍显示拉帕替尼治疗期间生活质量的稳定性,没有试验显示拉帕替尼对生活质量的不利影响。根据这些结果,讨论了生活质量评估在乳腺癌患者中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Review of the Impact of Lapatinib on Health-Related Quality of Life in the Management of Advanced Solid Tumors
Lapatinib is an oral dual inhibitor of epidermal growth factor receptor (HER1/ErbB1/EGFR) and human epidermal growth factor receptor 2 (HER2/ErbB2) which was approved for use in patients with metastatic breast cancer in 2007. In this review, we discuss the quality of life (QOL) results for patients on clinical trials of lapatinib. Six clinical trials, including 4 phase III and 2 phase II trials, were identified for which QOL outcomes have been reported. The trials generally showed stability of QOL during lapatinib therapy with no trial showing a detrimental effect of lapatinib on QOL. With these results, a discussion of the role of QOL assessments in patients with breast cancer is presented.
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