免疫受病毒性癌症的影响——综述

生命科学研究 Pub Date : 2014-11-24 DOI:10.2875/.V1I1.5

Yusuf Abrahim, Sarika Sharma, K. Daniel, V. Daniel

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引用次数: 0

摘要

T细胞反应识别和根除癌细胞。然而，T细胞消灭癌症只是癌症-免疫循环的一个步骤，它管理着自我识别和预防自身免疫之间的微妙平衡。癌细胞T细胞抑制信号的识别，包括pd - l1，促进了一类新的癌症免疫疗法的发展，这种疗法可以特异性地阻碍免疫效应抑制，重新激活并潜在地扩大先前存在的抗癌免疫反应。肿瘤微环境中抑制因子的存在可能解释了以前基于免疫的治疗所观察到的有限活性，以及为什么这些治疗与靶向周期其他步骤的药物联合使用可能更有效。新出现的临床数据表明，肿瘤免疫治疗很可能成为肿瘤临床管理的关键部分。关键词:免疫，病毒，肿瘤，人乳头瘤病毒，治疗。

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Immunity is Affected by Viral Cancer- A Review

ABSTRACT- T cell responses that recognize and eradicate cancer cells. However, elimination of cancer by T cells is only one step in the Cancer-Immunity Cycle, which manages the delicate balance between the recognition of onself and the prevention of autoimmunity. Identification of cancer cell T cell inhibitory signals, includingPD-L1, has prompted the development of a new class of cancer immunotherapy that specifically hindersmmune effector inhibition, reinvigorating and potentially expanding preexisting anticancer immune re-sponses. The presence of suppressive factors in the tumor microenvironment may explain the limited activityobserved with previous immune-based therapies and why these therapies may be more effective in combi-nation with agents that target other steps of the cycle. Emerging clinical data suggest that cancer immuno-therapy is likely to become a key part of the clinical management of cancer Keywords- Immunity, Virus ,Cancer, Human Papillomavirus,Therapy.

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来源期刊

生命科学研究

自引率

0.00%

发文量

2529

期刊介绍： "Life Science Research" is a comprehensive academic journal approved by the Press and Publication Administration of the People's Republic of China and the Ministry of Science and Technology. It is publicly distributed at home and abroad and reflects the latest research results in the field of life sciences. It is sponsored by the School of Life Sciences of Hunan Normal University. This journal mainly publishes creative academic papers in the field of life sciences at home and abroad, as well as a small number of news or review articles reflecting major progress or hot issues at home and abroad. The columns are mainly: Expert Forum, Exosome Column, Non-coding RNA Column, New Coronavirus Column, Ecology Column, Biochemistry and Molecular Biology, Genetics and Development, Tumor Mechanism, Cell and Physiology, Biological Classification, Bioinformatics, Basic Medicine, Technology and Application, University Teaching Reform Research and Practice, etc.