尼日利亚东南部阿巴卡利基北部和圣帕特里克医院4英里患者中基于人口统计学因素的耐多药结核病患病率

IF 7.6 2区 工程技术 Q1 CHEMISTRY, APPLIED
Chinenye Esther Okoro-Ani, C. Ugbor, S. Ibhawaegbele, I. Udoh, C. Igweagu, O. Dozie-Nwakile, Chima Gabriel Ezeah
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引用次数: 0

摘要

本研究旨在确定在NnamdiAzikiwe大学教学医院(NAUTH) Nnewi和圣帕特里克医院Mile 4 Abakaliki就诊的肺结核患者中耐多药结核病(MDR-TB)的流行情况。采用Ziehl-Neelsen ZN技术对持续咳嗽2周以上患者的痰液中是否存在抗酸杆菌(AFB)进行筛选,共招募了103例抗酸杆菌阳性的痰液样本。阳性痰样本进行Xpert MTB/RIF检测(GeneXpert®,Cepheid USA),并在Lowestein Jensen培养基上37°C培养42天。采用硝酸还原法(NRA)对分离菌株进行药敏试验。对疑似菌落进行形态学、生化和免疫学检测后,从培养中分离出83株(80.6%)分离菌株,经Xpert MTB/RIF试验分析的83株(80.6%)样品中45株(67.2%)对利福平耐药。26 ~ 35岁培养阳性比例最高(33.7%),其次为18 ~ 25岁(28.8%)。人口统计学上,26 ~ 35岁人群耐多药结核病患病率较高(50.0%),女性耐多药rb患病率也较高(48.5%)。引人注目的是,教育程度与耐多药结核病显著相关(P= 0.020)。圣帕特里克医院的耐多药结核病患病率(46.94%)高于诺思医院(38.9%),这表明在这些地方肺结核患者中耐多药结核病的患病率很高。这项研究的人口统计结果要求采取紧急和严肃的干预措施,因为耐多药结核病的流行率正在上升,即使面对强有力的国家结核病控制规划。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prevalence of MDR-TB Based on Demographic Factors Among Patients Attending Nauth and St Patrick’s Hospital Mile 4 Abakaliki in Southeast Nigeria
This study was designed to determine the prevalence of multi-drug resistant tuberculosis (MDR-TB) among pulmonary tuberculosis patients attending NnamdiAzikiwe University Teaching Hospital (NAUTH) Nnewi and St Patrick’s Hospital Mile 4 Abakaliki demographically. Patients with persistent cough for over two weeks were screened by Ziehl-Neelsen ZN technique for the presence of acid fast bacilli (AFB) in their sputum and a total of 103 patients with AFB positive sputum samples were recruited. The positive sputum samples were subjected to Xpert MTB/RIF assay (GeneXpert®, Cepheid USA) and culture on Lowestein Jensen medium for 42 days at 37°C. Drug susceptibility testing was done on the isolates using the nitrate reduction assay (NRA). Eighty-three 83 (80.6%) of the isolates were obtained from culture after suspected colonies were subjected to morphological, biochemical, and immunological tests and out of the 83 (80.6%) samples analysed by Xpert MTB/RIF assay 45 (67.2%) were rifampicin resistant. Age group 26-35 years showed the highest proportion of positive culture results (33.7%) followed by age group 18-25 (28.8%) years. Demographically, age group 26-35 years had a high prevalence rate of MDR-TB (50.0%) and female gender also showed high prevalence rate of MDR-RB (48.5%). Strikingly, educational status was significantly associated with MDR-TB (P=.020). St Patrick’s hospital had a high prevalence rate of MDR-TB (46.94%) when compared with NAUTH (38.9%) and these indicates that there is high prevalence of MDR-TB among patients with pulmonary TB in these sites. The demographic results of this study calls for urgent and serious intervention as MDR-TB prevalence is increasing even in the face of intense national TB control program.
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来源期刊
Annual review of chemical and biomolecular engineering
Annual review of chemical and biomolecular engineering CHEMISTRY, APPLIED-ENGINEERING, CHEMICAL
CiteScore
16.00
自引率
0.00%
发文量
25
期刊介绍: The Annual Review of Chemical and Biomolecular Engineering aims to provide a perspective on the broad field of chemical (and related) engineering. The journal draws from disciplines as diverse as biology, physics, and engineering, with development of chemical products and processes as the unifying theme.
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