RELATION BETWEEN VASCULER ENDOTHELIAL GROWTH FACTOR AND 3D DOPPLER ULTRASONOGRAPHY WITH SUBENDOMETRAIL WAVE LIKE MOVEMENT IN CASE OF UNEXPLAINED INFERTILITY

Unexplained infertility remains a frustrating problem for the clinician and a distressing condition for the affected couples. Unexplained infertility has been defined as it is the infertility which no cause can be detected to explain the fertility problem in spite of conventional investigation for both partners. to evaluate the Relation between Vasculer Endothelial Growth Factor (VEGF), sub endometrial wave like movement (JZC) and sub endometrial blood flow detected by 3D as indicator of uterine receptivity in spontnous and stimulated cycles in unexplained infertile women. The sample size was calculated according to Jain et al., (2015) who reported that the level of VEGF in fertile women was 324±20.50 and in infertile women the level was found to be 107.33±24.96. So, by adjusting the confidence interval to 95%, the power of the test to 90%, the ratio between groups was adjusted to 1:2. The sample size was found to be 96 cases divided into 32 controls (fertile women "group C") and 64 cases was divided also into two groups (infertile women with un-stimulated cycle (group A) and 32 cases infertile women with stimulated cycles chlomiphene citrate (group B). This study was performed in the department and out patient clinic of obstetrics and gynecology at Al Zahraa university hospital from September 2016 to September 2019 on ninety six participants. Ninety six participants who qualified the exclusion and inclusion criteria were enrolled in this study: thirty two participants categorized in group (A) diagnosed as unexplained infertility with unstimulated cycle, thirty two participants categorized in group (B) diagnesd as unexplained infertility with stimulated cycle (clomiphene citrate) and thirty two participants normal fertile women categorized in group (C) seeking contraceptive means (control group). All participants on day 21 -22 day of cycle underwent in to 3D transvaginal ultrasound to detect subendometrial blood flow, subendometial wave like movement and on the same day venous blood sample was taken to measure VEGF.