{"title":"胸腺酶α -1对实验性高胆固醇血症红细胞脂质水平和红细胞膜(Na(+)-K+)- atp酶活性的影响。","authors":"C. Gökkuşu, E. Ademoglu, H. Oz, U. Türkoğlu","doi":"10.7883/YOKEN1952.50.45","DOIUrl":null,"url":null,"abstract":"Thymosin alpha-1 is an active polypeptide isolated from thymus. This polypeptide is widely used in the diagnosis and treatment of many diseases, especially immune diseases. In this present study, we examined the effects of thymosin alpha-1 on plasma and erythrocyte lipid levels and the changes in erythrocyte membrane (Na+, K+)ATPase activity in hypercholesterolemic rabbits. The erythrocyte lipid levels decreased, whereas the erythrocyte membrane (Na+, K+)ATPase activity increased significantly in these rabbits after thymosin alpha-1 injection. These findings suggest that thymosin alpha-1 is effective on both the lipid level and erythrocyte membrane (Na+, K+)ATPase activity.","PeriodicalId":14531,"journal":{"name":"Japanese journal of medical science & biology","volume":"74 1","pages":"45-53"},"PeriodicalIF":0.0000,"publicationDate":"1997-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Effects of thymosin alpha-1 on erythrocyte lipid levels and erythrocyte membrane (Na(+)-K+)-ATPase activity in experimental hypercholesterolemia.\",\"authors\":\"C. Gökkuşu, E. Ademoglu, H. Oz, U. Türkoğlu\",\"doi\":\"10.7883/YOKEN1952.50.45\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Thymosin alpha-1 is an active polypeptide isolated from thymus. This polypeptide is widely used in the diagnosis and treatment of many diseases, especially immune diseases. In this present study, we examined the effects of thymosin alpha-1 on plasma and erythrocyte lipid levels and the changes in erythrocyte membrane (Na+, K+)ATPase activity in hypercholesterolemic rabbits. The erythrocyte lipid levels decreased, whereas the erythrocyte membrane (Na+, K+)ATPase activity increased significantly in these rabbits after thymosin alpha-1 injection. These findings suggest that thymosin alpha-1 is effective on both the lipid level and erythrocyte membrane (Na+, K+)ATPase activity.\",\"PeriodicalId\":14531,\"journal\":{\"name\":\"Japanese journal of medical science & biology\",\"volume\":\"74 1\",\"pages\":\"45-53\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1997-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Japanese journal of medical science & biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.7883/YOKEN1952.50.45\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Japanese journal of medical science & biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.7883/YOKEN1952.50.45","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effects of thymosin alpha-1 on erythrocyte lipid levels and erythrocyte membrane (Na(+)-K+)-ATPase activity in experimental hypercholesterolemia.
Thymosin alpha-1 is an active polypeptide isolated from thymus. This polypeptide is widely used in the diagnosis and treatment of many diseases, especially immune diseases. In this present study, we examined the effects of thymosin alpha-1 on plasma and erythrocyte lipid levels and the changes in erythrocyte membrane (Na+, K+)ATPase activity in hypercholesterolemic rabbits. The erythrocyte lipid levels decreased, whereas the erythrocyte membrane (Na+, K+)ATPase activity increased significantly in these rabbits after thymosin alpha-1 injection. These findings suggest that thymosin alpha-1 is effective on both the lipid level and erythrocyte membrane (Na+, K+)ATPase activity.
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