Effect of CEA on neurological function and coagulation function in patients with ischemic stroke

Objective To observe the effect of carotid endarterectomy (CEA) on the patients with ischemic stroke, and to observe the effect on the function of nerve and blood coagulation. Methods The patients who were treated with ischemic stroke in our hospital from February 2017 to December 2017 were selected as the research subjects. According to the treatment methods, the patients were divided into the carotid angioplasty stenting (CAS) group (n=45) and the CEA treatment group (n=45). The therapeutic effects of the two groups were observed, and the differences of coagulation function and quality of life between the two groups before and after treatment were compared. Results The effective rate of treatment in the CEA treatment group was 97.78%, which was significantly higher than that of the CAS group (χ2=4.939, P=0.026). The two groups had no difference in coagulation function before treatment. After the treatment, the levels of activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT) and D-dimer (D-D) in the CEA group were lower than those in the CAS group (t=22.801, 3.752, 6.039, 169.556, P<0.05). There was no difference in the quality of life between the two groups before treatment. After treatment, the quality of life of the CEA treatment group was higher than that of the CAS group (P<0.05). The incidence of high perfusion syndrome, restenosis and hematoma in group CEA was lower than that in group CAS (χ2=4.406, P=0.036). Conclusions CEA has good therapeutic effect on patients with ischemic stroke. It can obviously improve the nerve function and coagulation function of patients, and has a good application value. Key words: Endarterectomy, carotid; Stroke; Neurological function; Coagulation function