蛇尾草根提取物对小鼠甲状腺功能亢进的调节作用

S. Panda, A. Kar
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引用次数: 10

摘要

本研究的目的是确定蛇纹草根提取物对小鼠甲状腺功能亢进症的调节作用。l -甲状腺素(50 μg/100 g,连续30天)处理小鼠血清中甲状腺激素(甲状腺素和三碘甲状腺原氨酸)浓度和肝脏葡萄糖-6-磷酸酶活性均升高。每天单独或与甲状腺素一起服用植物提取物(2.5 mg kg−1)30天,可降低两种甲状腺激素的浓度,表明植物提取物可能调节甲状腺功能亢进。该植物提取物还能降低甲亢小鼠肝脏脂质过氧化,增加超氧化物歧化酶和过氧化氢酶活性,但无肝毒性作用。蛇鞭草根提取物可能是治疗甲亢的潜在有效药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Regulation of Hyperthyroidism by Rauwolfia serpentina Root Extract in Mice
The aim of this study was to determine the role of Rauwolfia serpentina root extract in the regulation of hyperthyroidism in mice. In L-thyroxine (50 μg/100 g for 30 days)-treated mice, an increase in serum concentrations of both thyroid hormones (thyroxine and triiodothyronine) and in hepatic glucose-6-phosphatase activity was observed. Daily administration of the plant extract (2.5 mg kg−1) either alone or with thyroxine for 30 days decreased concentrations of both thyroid hormones, indicating the possible regulation of hyperthyroidism by the plant extract. The plant extract also decreased hepatic lipid peroxidation and increased super-oxide dismutase and catalase activity in hyperthyroid mice without hepatotoxic effects. R. serpentina root extract might be a potentially effective treatment for hyperthyroidism.
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