P'

Here, an efficient and biodegradable catalytic system prepared through a simple procedure is presented by using chitosan (Cs), epichlorohydrin (ECH) and trimesic acid (TMA). The obtained bio-based Cs/ECH-TMA was characterized by using different spectroscopic and analytical methods. The Cs-ECH-TMA biopolymeric materials were used, as a bifunctional heterogeneous and green catalyst, for efficient synthesis of biologically-active scaffolds including polyhydroquinolines (PHQs) and acridinediones through Hantzsch reaction in a one-pot reaction. Both PHQs and acridinediones were synthesized in the presence of heterogeneous Cs/ECH-TMA catalyst from their corresponding substrates in EtOH under reflux conditions in high to quantitative yields. The Cs/ECH-TMA catalyst is recyclable and can be reused at least five times.