{"title":"用近红外反射光谱法实时监测固相合成中的非破坏性反应-树脂结合醇的酯化反应","authors":"Jonathan Hammond, A. Moffat, R. D. Jee, B. Kellam","doi":"10.1039/A900747D","DOIUrl":null,"url":null,"abstract":"Near-infrared (NIR) reflectance spectroscopy has been used to monitor the chemical inter-conversion of resin-bound functional groups. Measurements required no sample preparation and were made directly through the bottom of the glass reaction vessel. The time–concentration profile of the esterification of a resin-bound alcohol by acetic anhydride in a toluene medium is demonstrated.","PeriodicalId":7814,"journal":{"name":"Analytical Communications","volume":"180 1","pages":"127-129"},"PeriodicalIF":0.0000,"publicationDate":"1999-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"10","resultStr":"{\"title\":\"Non-destructive real-time reaction monitoring in solid phase synthesis by near-infrared reflectance spectroscopy—esterification of a resin-bound alcohol\",\"authors\":\"Jonathan Hammond, A. Moffat, R. D. Jee, B. Kellam\",\"doi\":\"10.1039/A900747D\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Near-infrared (NIR) reflectance spectroscopy has been used to monitor the chemical inter-conversion of resin-bound functional groups. Measurements required no sample preparation and were made directly through the bottom of the glass reaction vessel. The time–concentration profile of the esterification of a resin-bound alcohol by acetic anhydride in a toluene medium is demonstrated.\",\"PeriodicalId\":7814,\"journal\":{\"name\":\"Analytical Communications\",\"volume\":\"180 1\",\"pages\":\"127-129\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1999-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"10\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Analytical Communications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1039/A900747D\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Analytical Communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1039/A900747D","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Non-destructive real-time reaction monitoring in solid phase synthesis by near-infrared reflectance spectroscopy—esterification of a resin-bound alcohol
Near-infrared (NIR) reflectance spectroscopy has been used to monitor the chemical inter-conversion of resin-bound functional groups. Measurements required no sample preparation and were made directly through the bottom of the glass reaction vessel. The time–concentration profile of the esterification of a resin-bound alcohol by acetic anhydride in a toluene medium is demonstrated.