{"title":"[丙型肝炎病毒非结构蛋白NS4B对ifn - γ受体信号的抑制作用]。","authors":"Yi Zheng, Hai-bo Luo, B. Gao, Laiqiang Huang","doi":"10.3760/CMA.J.ISSN.1008-1372.2008.11.010","DOIUrl":null,"url":null,"abstract":"The function of NS4B is incompletely understood. The aim of the study is to understand the influence of NS4B on anti-viral response. After cell line stably expressing NS4B established, the influence of IFN-alpha of different concentration on VSV was studied using plaque assay; cell expression profiling caused by NS4B was studied using DNA microarray, and the IFNGR1 fluorescence intensity was analyzed. Our data showed that HCV-NS4B could suppress immuno-associated gene expression, in particular, IFN-gamma receptor signal transduction-related genes. Taken together, NS4B could play some roles in HCV resistance to IFN therapy.","PeriodicalId":67785,"journal":{"name":"微体古生物学报","volume":"20 1","pages":"802-6"},"PeriodicalIF":0.0000,"publicationDate":"2006-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Inhibition of IFN-gamma receptor signaling by hepatitis C virus non-structural protein NS4B].\",\"authors\":\"Yi Zheng, Hai-bo Luo, B. Gao, Laiqiang Huang\",\"doi\":\"10.3760/CMA.J.ISSN.1008-1372.2008.11.010\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The function of NS4B is incompletely understood. The aim of the study is to understand the influence of NS4B on anti-viral response. After cell line stably expressing NS4B established, the influence of IFN-alpha of different concentration on VSV was studied using plaque assay; cell expression profiling caused by NS4B was studied using DNA microarray, and the IFNGR1 fluorescence intensity was analyzed. Our data showed that HCV-NS4B could suppress immuno-associated gene expression, in particular, IFN-gamma receptor signal transduction-related genes. Taken together, NS4B could play some roles in HCV resistance to IFN therapy.\",\"PeriodicalId\":67785,\"journal\":{\"name\":\"微体古生物学报\",\"volume\":\"20 1\",\"pages\":\"802-6\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2006-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"微体古生物学报\",\"FirstCategoryId\":\"1089\",\"ListUrlMain\":\"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2008.11.010\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"微体古生物学报","FirstCategoryId":"1089","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2008.11.010","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
[Inhibition of IFN-gamma receptor signaling by hepatitis C virus non-structural protein NS4B].
The function of NS4B is incompletely understood. The aim of the study is to understand the influence of NS4B on anti-viral response. After cell line stably expressing NS4B established, the influence of IFN-alpha of different concentration on VSV was studied using plaque assay; cell expression profiling caused by NS4B was studied using DNA microarray, and the IFNGR1 fluorescence intensity was analyzed. Our data showed that HCV-NS4B could suppress immuno-associated gene expression, in particular, IFN-gamma receptor signal transduction-related genes. Taken together, NS4B could play some roles in HCV resistance to IFN therapy.
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