{"title":"山参叶甲醇组分抗溃疡作用的研究","authors":"S. Nwafor","doi":"10.4314/AJST.V5I1.15325","DOIUrl":null,"url":null,"abstract":"Fraction F1 containing alkaloids and sterols/triterpenes isolated from the methanolic leaf extract of Cissampelos mucronata A.Rich (Menispermaceae) was assayed for anti-ulcer activity using histamine- and stress-induced ulcer models. The fraction and crude methanolic extract (CME) were screened for anti-spasmodic activity using the spontaneously contracting smooth muscle of the rabbit jejunum. Their antimicrobial potency was assessed using different Gram-negative and Grampositive bacteria as well as two species of fungi. The result indicate that the fraction and CME exhibited 63.25 % and 57.26 % inhibition of ulcer induced by histamine while 57.15 % and 47.14 % inhibition were recorded against stress-induced ulcer respectively. The inhibitions of ulcer induction were significant (P Key Words: Cissampelos mucronata, fraction, histamine, stress African Journal of Science and Technology Vol.5(1) 2004:109-114","PeriodicalId":7641,"journal":{"name":"African Journal of Science and Technology","volume":"63 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2005-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"8","resultStr":"{\"title\":\"INVESTIGATION OF THE ANTIULCER PROPERTIES OF THE METHANOLIC LEAF FRACTION OF CISSAMPELOS MUCRONATA\",\"authors\":\"S. Nwafor\",\"doi\":\"10.4314/AJST.V5I1.15325\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Fraction F1 containing alkaloids and sterols/triterpenes isolated from the methanolic leaf extract of Cissampelos mucronata A.Rich (Menispermaceae) was assayed for anti-ulcer activity using histamine- and stress-induced ulcer models. The fraction and crude methanolic extract (CME) were screened for anti-spasmodic activity using the spontaneously contracting smooth muscle of the rabbit jejunum. Their antimicrobial potency was assessed using different Gram-negative and Grampositive bacteria as well as two species of fungi. The result indicate that the fraction and CME exhibited 63.25 % and 57.26 % inhibition of ulcer induced by histamine while 57.15 % and 47.14 % inhibition were recorded against stress-induced ulcer respectively. The inhibitions of ulcer induction were significant (P Key Words: Cissampelos mucronata, fraction, histamine, stress African Journal of Science and Technology Vol.5(1) 2004:109-114\",\"PeriodicalId\":7641,\"journal\":{\"name\":\"African Journal of Science and Technology\",\"volume\":\"63 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2005-02-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"8\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"African Journal of Science and Technology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4314/AJST.V5I1.15325\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"African Journal of Science and Technology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4314/AJST.V5I1.15325","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
INVESTIGATION OF THE ANTIULCER PROPERTIES OF THE METHANOLIC LEAF FRACTION OF CISSAMPELOS MUCRONATA
Fraction F1 containing alkaloids and sterols/triterpenes isolated from the methanolic leaf extract of Cissampelos mucronata A.Rich (Menispermaceae) was assayed for anti-ulcer activity using histamine- and stress-induced ulcer models. The fraction and crude methanolic extract (CME) were screened for anti-spasmodic activity using the spontaneously contracting smooth muscle of the rabbit jejunum. Their antimicrobial potency was assessed using different Gram-negative and Grampositive bacteria as well as two species of fungi. The result indicate that the fraction and CME exhibited 63.25 % and 57.26 % inhibition of ulcer induced by histamine while 57.15 % and 47.14 % inhibition were recorded against stress-induced ulcer respectively. The inhibitions of ulcer induction were significant (P Key Words: Cissampelos mucronata, fraction, histamine, stress African Journal of Science and Technology Vol.5(1) 2004:109-114
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