Noor Ghaffar Said Al Habooby, N. Yousif, N. Hadi, J. J. Al-Baghdadi
{"title":"维生素D通过降低I/R诱导的ERK磷酸化减轻小鼠心肌损伤","authors":"Noor Ghaffar Said Al Habooby, N. Yousif, N. Hadi, J. J. Al-Baghdadi","doi":"10.2174/2213988501812010027","DOIUrl":null,"url":null,"abstract":"Received: August 24, 2018 Revised: October 4, 2018 Accepted: October 10, 2018 Abstract: Objectives: Myocardial injury caused by ischemia followed by reperfusion mediates a complex series of inflammatory response that reduces the benefit of medical interventions, such as percutaneous coronary intervention, thrombolytic therapy, and coronary bypass surgery. Therefore, suppression of Ischemia/Reperfusion (I/R) -mediated myocardial injury is important in clinical practice. The objective of this study was to investigate whether vitamin has some protective effect on heart after myocardial I/R, and the mechanistic pathway of this effect.","PeriodicalId":10755,"journal":{"name":"Current Chemical Genomics and Translational Medicine","volume":"36 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"7","resultStr":"{\"title\":\"Vitamin D Attenuates Myocardial Injury by Reduces ERK Phosphorylation Induced by I/R in Mice Model\",\"authors\":\"Noor Ghaffar Said Al Habooby, N. Yousif, N. Hadi, J. J. Al-Baghdadi\",\"doi\":\"10.2174/2213988501812010027\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Received: August 24, 2018 Revised: October 4, 2018 Accepted: October 10, 2018 Abstract: Objectives: Myocardial injury caused by ischemia followed by reperfusion mediates a complex series of inflammatory response that reduces the benefit of medical interventions, such as percutaneous coronary intervention, thrombolytic therapy, and coronary bypass surgery. Therefore, suppression of Ischemia/Reperfusion (I/R) -mediated myocardial injury is important in clinical practice. The objective of this study was to investigate whether vitamin has some protective effect on heart after myocardial I/R, and the mechanistic pathway of this effect.\",\"PeriodicalId\":10755,\"journal\":{\"name\":\"Current Chemical Genomics and Translational Medicine\",\"volume\":\"36 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-12-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"7\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Chemical Genomics and Translational Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/2213988501812010027\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Chemical Genomics and Translational Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/2213988501812010027","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Vitamin D Attenuates Myocardial Injury by Reduces ERK Phosphorylation Induced by I/R in Mice Model
Received: August 24, 2018 Revised: October 4, 2018 Accepted: October 10, 2018 Abstract: Objectives: Myocardial injury caused by ischemia followed by reperfusion mediates a complex series of inflammatory response that reduces the benefit of medical interventions, such as percutaneous coronary intervention, thrombolytic therapy, and coronary bypass surgery. Therefore, suppression of Ischemia/Reperfusion (I/R) -mediated myocardial injury is important in clinical practice. The objective of this study was to investigate whether vitamin has some protective effect on heart after myocardial I/R, and the mechanistic pathway of this effect.
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