三组分反应高效合成含稳定磷酰化基团的5-羟基-1-苯基- 1h -吡唑

Ehsan Ghonchepour, M. Islami, H. Mostafavi, Ahmad Momeni Tikdari
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引用次数: 8

摘要

摘要:本文以易得的有机化合物为原料,合成了一种含磷烷的新型多取代吡唑。这种C-H键功能化是一种选择性取代吡唑4位的有效方法,它可以生成含有乙烯基的五元芳香环。该方法不需要额外的催化剂,可用于包括不同取代基的其他吡唑。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Three-component reaction for an efficient synthesis of 5-hydroxy-1-phenyl-1H-pyrazoles containing a stable phosphorus ylide moiety
GRAPHICAL ABSTRACT ABSTRACT A concise synthesis of new polysubstituted pyrazoles containing a phosphorane is achieved from readily available organic compounds. This C–H bond functionalization is an efficient means of selectively substituting 4-position of pyrazole to produce a five-membered aromatic ring with a chain containing ylide moiety. This protocol requires no additional catalyst and can be used for other pyrazoles including different substituents.
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