全身热疗作为放射治疗转移性肛囊腺癌犬的辅助治疗

IF 0.2 4区 农林科学 Q4 VETERINARY SCIENCES
S. Janssen, B. Wylleman, K. Kromhout, J. Benoît, S. Marynissen, I. Van de Maele, H. de Rooster
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引用次数: 0

摘要

一名11岁的Galgo Espagnol被诊断为转移性肛囊腺癌。该患者参加了一项临床试验,在十周的时间内接受了三次“全身热疗法”(WBTT)和四次低分割放疗。医疗器械和相应的治疗方案由ElmediX (ElmediX NV,比利时)设计。在治疗室中高速注入空气,自动调节达到并保持体温41.5℃8小时。通过放置在患者体内和身上的温度传感器来确保测温。在四次放射治疗期间,一束外照射对原发肿瘤和转移性淋巴结均给予6Gy的低分割剂量。临床监测和生活质量评估证实WBTT疗程耐受性良好。虽然在压力点出现烧伤创面,但未观察到长期严重的不良反应。此外,疾病进展被认为比基于文献的预期进展慢。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Whole-body thermal therapy as adjuvant therapy to radiation in a dog with metastasized anal sac adenocarcinoma
An eleven-year-old Galgo Espagnol was diagnosed with metastasized anal sac adenocarcinoma. The patient was enrolled into a clinical trial and underwent three “whole-body thermal therapy” (WBTT) sessions combined with four hypofractionated radiotherapy sessions during a ten-weeks’ time period. The medical device and corresponding treatment protocol were designed by ElmediX (ElmediX NV, Belgium). Air was injected at high speed in a treatment chamber and automatically regulated to reach and maintain a body temperature of 41.5°C for eight hours. Thermometry was ensured by temperature sensors placed in and on the patient. During four radiotherapy sessions, an external beam delivered hypofractionated doses of 6Gy on both the primary tumor and the metastatic lymph nodes. Clinical monitoring and assessment of quality of life confirmed that the WBTT sessions were well tolerated. Although burn wounds at pressure points occurred, prolonged severe adverse effects were not observed. Furthermore, the disease progression was deemed slower than the expected progression based on the literature.
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来源期刊
Vlaams Diergeneeskundig Tijdschrift
Vlaams Diergeneeskundig Tijdschrift 农林科学-兽医学
CiteScore
0.40
自引率
0.00%
发文量
29
审稿时长
>36 weeks
期刊介绍: The Vlaams Diergeneeskundig Tijdschrift (ISSN 0303-9021) is a scientific journal that is published bimonthly (six issues per year). It presents mainly clinical topics and addresses itself to two very different readerships: the local Dutch speaking veterinarians in Belgium and the Netherlands, and the international veterinary and biomedical research community. Each issue contains scientific papers either in English, or in Dutch with an English abstract.
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