合成代谢-雄激素类固醇对摩苏尔市健身者男性激素的影响

Abdulrahman Mazin Hashim, S. H. Almukhtar
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摘要

合成代谢雄激素类固醇(AAS)的滥用在世界范围内呈增长趋势,尤其是在男性健美运动员和健身房爱好者中滥用,以增强肌肉来改善他们的外表。滥用AAS被认为是男性生育能力的可预防因素,因为它影响下丘脑-垂体-性腺轴,导致继发性男性性腺功能减退,然后短暂或持续抑制精子发生。本研究旨在探讨合成代谢类固醇滥用对血清促卵泡激素、黄体生成素和游离睾酮浓度的影响。本文对摩苏尔市80名健康男性健身者进行了前瞻性队列研究,将其分为病例组和对照组。在2020年10月25日至2021年3月15日期间,使用结构化访谈问卷收集与AAS滥用相关的信息,并在私人分析实验室收集血液样本以评估男性激素。研究发现,AAS组男性激素在促卵泡激素、黄体生成素和游离睾酮的血清浓度的总体平均值上表现出高度显著性(p >0.001)。ROC曲线分析显示男性激素差异极显著(p >0.001),其中促卵泡激素曲线下面积为0.94,黄体生成素曲线下面积为0.93,游离睾酮曲线下面积为0.81。滥用AAS会导致促性腺激素和游离睾酮浓度的严重下降,这可能被认为是继发性男性性腺功能减退的一个很好的预测指标。该研究建议有必要防止滥用合成代谢类固醇,并说明使用它的不利影响,特别是对生育能力的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Influence of Anabolic-Androgenic Steroids on Males’ Hormones Among Gym-Goers in Mosul City
Anabolic-Androgenic Steroids (AAS) misuse are growing worldwide and misused especially among male bodybuilders and gyms-goers for building muscle to improve their physical appearance. AAS misuse is considered a preventable factor of male fertility because it affects the hypothalamic-pituitary-gonadal axis resulting in secondary male hypogonadism, and then transient or persistent suppression of spermatogenesis. Study aimed to investigate the influence of anabolic steroids misuse on the serum concentrations of follicle stimulating hormone, luteinizing hormone, and free testosterone. A prospective cohort study was conducted on 80 healthy male gym-goers divided into the case and control group who attending gyms in Mosul city. A structured interviewing questionnaire was used to collect information related to AAS misuse, blood sampling collected for evaluation of males' hormones in a private analytics Lab, for a period 25th October 2020 until 15th March 2021. Study finding shows that males' hormones of AAS group exhibited highly significant (P.>0.001) in the overall mean of serum concentrations of follicle stimulating hormone, luteinizing hormone, and free testosterone. ROC curve analysis reveals a highly significant deference at (P.>0.001) of males' hormones, which area under the curve was for follicle stimulating hormone: 0.94, luteinizing hormone: 0.93, and free testosterone: 0.81. The misuse of AAS exhibited a severe decrease in concentrations of gonadotropins and free testosterone with may be considered an excellent predictor of secondary male hypogonadism. The study recommends the necessity to prevent abuse of anabolic steroids and instruct about the adverse effects that result from using it and especially on fertility.
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