磺胺类新衍生物的合成及抗氧化活性研究

Jovana Muskinja, Jelena S. Katanić Stanković, Z. Ratković
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引用次数: 0

摘要

磺胺衍生物是一类非常重要的化合物,具有显著的生物活性,因此具有非常有用的制药应用。它们是几组药物的基础,被称为磺胺类药物。从这个角度来看,本研究的重点是合成一些新的结构杂化化合物,其中包括两个非常重要的基团,磺胺和吡唑啉。合成了新的磺胺基吡唑啉,收率很高。通过红外光谱和核磁共振等方法对化合物的结构进行了确证。采用DPPH自由基清除法和ABTS自由基清除法测定合成化合物的抗氧化活性。结果表明,其体外抗氧化活性较好。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
SYNTHESIS AND ANTIOXIDANT ACTIVITY OF SOME NEW SULFONAMIDE DERIVATIVES
Sulfonamide derivatives are a very important class of compounds with pronounced biological activities and, for this reason, they have very useful pharmaceutical applications. They are the basis of several groups of drugs and are known as sulfa-drugs. From this point of view, the present study focuses on the synthesis of some novel structural hybrids incorporating two very important groups, sulfonamide, and pyrazoline. The new sulfonamide-based pyrazolines were synthesized in very good yields. The structures of the sulfonamide compounds were confirmed by IR and NMR methods. Synthesized compounds were tested for their antioxidant activities using two different methods, DPPH radical and ABTS radical cation scavenging assays. The results showed relatively good in vitro antioxidant activity.
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