{"title":"从克隆选择概念到疏水性理论","authors":"D. Kanduc","doi":"10.12988/asb.2022.91410","DOIUrl":null,"url":null,"abstract":"This article 1) reviews the concepts of clonal selection and deletion of self-reactive lymphocytes that, although formulated about 70 years ago, have never been experimentally validated until now, and 2) indicates hydrophobicity as the physico-chemical factor able to prevent self-reactivity, thus governing immunotolerance and immunogenicity.","PeriodicalId":7194,"journal":{"name":"Advanced Studies in Biology","volume":"16 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"From the clonal selection concept to the hydrophobicity theory\",\"authors\":\"D. Kanduc\",\"doi\":\"10.12988/asb.2022.91410\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This article 1) reviews the concepts of clonal selection and deletion of self-reactive lymphocytes that, although formulated about 70 years ago, have never been experimentally validated until now, and 2) indicates hydrophobicity as the physico-chemical factor able to prevent self-reactivity, thus governing immunotolerance and immunogenicity.\",\"PeriodicalId\":7194,\"journal\":{\"name\":\"Advanced Studies in Biology\",\"volume\":\"16 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advanced Studies in Biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.12988/asb.2022.91410\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Studies in Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.12988/asb.2022.91410","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
From the clonal selection concept to the hydrophobicity theory
This article 1) reviews the concepts of clonal selection and deletion of self-reactive lymphocytes that, although formulated about 70 years ago, have never been experimentally validated until now, and 2) indicates hydrophobicity as the physico-chemical factor able to prevent self-reactivity, thus governing immunotolerance and immunogenicity.
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