单花大叶草的保肝作用Verdc。对乙酰氨基酚种子提取物对Wistar白化大鼠肝毒性的影响

Mohgana Ramasamy, Anbu Jeba Sunilson John Samuel, Anandarajagopal Kalusalingam, Krupavaram Bethala
{"title":"单花大叶草的保肝作用Verdc。对乙酰氨基酚种子提取物对Wistar白化大鼠肝毒性的影响","authors":"Mohgana Ramasamy, Anbu Jeba Sunilson John Samuel, Anandarajagopal Kalusalingam, Krupavaram Bethala","doi":"10.9734/BJPR/2017/32457","DOIUrl":null,"url":null,"abstract":"Background: Macrotyloma uniflorum (Horse gram) seeds are used in Ayurvedic medicine for treating numerous health disorders including rheumatism, worm, conjunctivitis and piles. The seeds were boiled with water and used as a folklore medicine for treatment of jaundice in Andhra Pradesh, India. Aim: The present study was aimed to find out the therapeutic potentials of M. uniflorum seeds Original Research Article Mohgana et al.; BJPR, 15(5): 1-9, 2017; Article no.BJPR.32457 2 extract against paracetamolinduced hepatotoxicity and also to scientifically prove its traditional claim. Methodology: Hepatotoxicity was induced in wistar albino rats by the oral administration of paracetamol (400 mg/kg b.wt.) for 10 days. The ethanolic extract and water extract (400 mg/kg b.wt.) were orally administered to the respective group once daily for 10 days. Silymarin (20 mg/kg b.wt.) was used as standard. Biochemical parameters such as ASAT, ALAT, ALP, TP, albumin, globulin, total bilirubin and GGT were determined to assess the hepatoprotective effect. Results: The oral administration of both ethanolic and water extracts significantly (P<0.001) restored the biochemical parameters in the hepatotoxicated rats which were well compared with standard drug silymarin. The hepatoprotective activity of ethanolic extract provides therapeutically better efficacy which was further supported by histopathological examination. The phytochemical screening reveals the presence of phytoconstituents such as phenolic compounds, flavonoids and alkaloids which might be responsible for the hepatoprotective activity. Conclusion: The scientific establishment of the M. uniflorum was traditionally claimed by folklore medicine was validated.","PeriodicalId":9320,"journal":{"name":"British journal of pharmaceutical research","volume":"23 1","pages":"1-9"},"PeriodicalIF":0.0000,"publicationDate":"2017-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Hepatoprotective Activity of Macrotyloma uniflorum (Lam.) Verdc. Seeds Extracts Against Paracetamol Induced Hepatotoxicity in Wistar Albino Rats\",\"authors\":\"Mohgana Ramasamy, Anbu Jeba Sunilson John Samuel, Anandarajagopal Kalusalingam, Krupavaram Bethala\",\"doi\":\"10.9734/BJPR/2017/32457\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Macrotyloma uniflorum (Horse gram) seeds are used in Ayurvedic medicine for treating numerous health disorders including rheumatism, worm, conjunctivitis and piles. The seeds were boiled with water and used as a folklore medicine for treatment of jaundice in Andhra Pradesh, India. Aim: The present study was aimed to find out the therapeutic potentials of M. uniflorum seeds Original Research Article Mohgana et al.; BJPR, 15(5): 1-9, 2017; Article no.BJPR.32457 2 extract against paracetamolinduced hepatotoxicity and also to scientifically prove its traditional claim. Methodology: Hepatotoxicity was induced in wistar albino rats by the oral administration of paracetamol (400 mg/kg b.wt.) for 10 days. The ethanolic extract and water extract (400 mg/kg b.wt.) were orally administered to the respective group once daily for 10 days. Silymarin (20 mg/kg b.wt.) was used as standard. Biochemical parameters such as ASAT, ALAT, ALP, TP, albumin, globulin, total bilirubin and GGT were determined to assess the hepatoprotective effect. Results: The oral administration of both ethanolic and water extracts significantly (P<0.001) restored the biochemical parameters in the hepatotoxicated rats which were well compared with standard drug silymarin. The hepatoprotective activity of ethanolic extract provides therapeutically better efficacy which was further supported by histopathological examination. The phytochemical screening reveals the presence of phytoconstituents such as phenolic compounds, flavonoids and alkaloids which might be responsible for the hepatoprotective activity. Conclusion: The scientific establishment of the M. uniflorum was traditionally claimed by folklore medicine was validated.\",\"PeriodicalId\":9320,\"journal\":{\"name\":\"British journal of pharmaceutical research\",\"volume\":\"23 1\",\"pages\":\"1-9\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-01-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"British journal of pharmaceutical research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.9734/BJPR/2017/32457\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"British journal of pharmaceutical research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.9734/BJPR/2017/32457","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1

摘要

背景:马属植物的种子在阿育吠陀医学中用于治疗许多健康疾病,包括风湿病、蠕虫、结膜炎和痔疮。在印度的安得拉邦,人们将这种种子与水一起煮熟,并将其用作治疗黄疸的民间药物。前言:目的:研究一花支原体种子的治疗潜力。生物工程学报,15(5):1-9,2017;文章no.BJPR。324572提取物抗扑热息痛引起的肝毒性,并科学地证明其传统说法。方法:口服扑热息痛(400mg /kg b.w.t .) 10 d诱导wistar白化大鼠肝毒性。分别给予乙醇提取物和水提取物(400 mg/kg b.wt.),每天1次,连用10 d。水飞蓟素(20 mg/kg b.wt.)作为标准品。测定ASAT、ALAT、ALP、TP、白蛋白、球蛋白、总胆红素、GGT等生化指标评价其保肝作用。结果:水飞蓟素对肝中毒大鼠的生化指标均有显著的恢复作用(P<0.001),且与标准药水飞蓟素相比效果较好。乙醇提取物的肝保护活性具有较好的治疗效果,组织病理学检查进一步证实了这一点。植物化学筛选表明,植物成分如酚类化合物、类黄酮和生物碱的存在可能负责保护肝脏的活性。结论:民间传统医学所称的一瓣草的科学依据得到了验证。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hepatoprotective Activity of Macrotyloma uniflorum (Lam.) Verdc. Seeds Extracts Against Paracetamol Induced Hepatotoxicity in Wistar Albino Rats
Background: Macrotyloma uniflorum (Horse gram) seeds are used in Ayurvedic medicine for treating numerous health disorders including rheumatism, worm, conjunctivitis and piles. The seeds were boiled with water and used as a folklore medicine for treatment of jaundice in Andhra Pradesh, India. Aim: The present study was aimed to find out the therapeutic potentials of M. uniflorum seeds Original Research Article Mohgana et al.; BJPR, 15(5): 1-9, 2017; Article no.BJPR.32457 2 extract against paracetamolinduced hepatotoxicity and also to scientifically prove its traditional claim. Methodology: Hepatotoxicity was induced in wistar albino rats by the oral administration of paracetamol (400 mg/kg b.wt.) for 10 days. The ethanolic extract and water extract (400 mg/kg b.wt.) were orally administered to the respective group once daily for 10 days. Silymarin (20 mg/kg b.wt.) was used as standard. Biochemical parameters such as ASAT, ALAT, ALP, TP, albumin, globulin, total bilirubin and GGT were determined to assess the hepatoprotective effect. Results: The oral administration of both ethanolic and water extracts significantly (P<0.001) restored the biochemical parameters in the hepatotoxicated rats which were well compared with standard drug silymarin. The hepatoprotective activity of ethanolic extract provides therapeutically better efficacy which was further supported by histopathological examination. The phytochemical screening reveals the presence of phytoconstituents such as phenolic compounds, flavonoids and alkaloids which might be responsible for the hepatoprotective activity. Conclusion: The scientific establishment of the M. uniflorum was traditionally claimed by folklore medicine was validated.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信