Contemplating the Relevance and Efficacy of Miswak (Salvadora Persica) inScientific Era: A Comprehensive Care from the Treasures of Tibbe Nabawi(Prophetic Medicine)

Background: Miswak ( Salvadora persica ) was employed by the Babylonians 7000 years ago followed by the Greek, Romans, Egyptians and Islamic empires. Persistence of Miswak nowadays is especially of a spiritual character and is usually utilized in Muslim countries. The Messenger of Allah, Muhammed (PBUH), in several narrations in authentic religious scriptures emphasizes the importance of miswak. “Miswak cleanses the mouth, sharpens eyesight, strengthens the gums, whitens the teeth, prevents cavity, facilitates digestion, restores the stomach to health, brings an end to the phlegm, and multiplies good deeds. An individual employing a miswak pleases Allah subhanahuta’ala and delights angels.” (Abu Nu’aym) The miswak has numerous benefits, the lightest of which is that it dispels distress. Besides, it also slows the aging process. Objective: To explore the various narrations of Prophet Muhammad (PBUH) in authentic scriptures about Miswak ( Salvadora persica ) and to rule out its efficacy on the basis of scientific studies. Methods: Thorough literature review including Ahadith and various scientific studies including those conducted by World Health Organization related to Miswak to serve the objective. Discussion: In numerous studies conducted by the World Health Organization, and other independent research groups, Miswak has been shown to contain variety of active anti-bacterial compounds that actively fight bacterial growth within the mouth. Many epidemiological studies revealed that it had strong anti-decay effects. Strong evidence from the available descriptive and experimental studies supports the view that it are often a potent oral hygiene tool. Antioxidant enzymes like peroxidase, catalase, and polyphenol oxidase present in Miswak are said to possess anti-carcinogenic properties. Additionally, the active ingredients present in Miswak have analgesic, or pain relieving properties that help affect inflammation and pain, especially within the gums. Conclusion: It has numerous antibacterial qualities which makes it a perfect alternative to the modern day toothbrush. Its use as a preventive measure has been established via research. Vesicle based model protocells were regulated by the incorporated DNA length, and not the base pair sequence due to the presence of a supramolecular catalyst (lipo-deoxyribozyme) composed of DNA and lipophilic catalysts. The DNA length dependent dynamics of the self-reproducing GVs containing different length of DNA were examined by three independent experiments; Population analysis by flow cytometric measurements, counting of increased numbers of protocells and direct morphological observation of a single GV by confocal microscopy. These results may shed light on the information system in the prebiotic stage, when the central dogma was not established. Notably, recent reports have revealed the possible influence of DNA length on the activation of living cells through the complexation of DNA to an enzyme in non-sequential aggregation manner.