选择性干牛治疗方案中不同乳封剂与乳内抗菌剂的相容性评价

Gazza Carlo,
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引用次数: 0

摘要

干乳期是哺乳周期的关键时期,是新发感染的易感性最高的时期,也是治疗已有乳内感染的最佳时机。在选择性干奶牛抗菌治疗中,我们有两种不同的方式介入干期的管理治疗:第一种情况下,奶牛被诊断为健康,只使用乳封剂治疗;第二种情况下,患有致病性乳腺炎或细胞计数高的奶牛将接受乳内治疗和乳封剂。乳内密封剂的主要优点之一是确保它在整个干燥期保持在乳头内。为了保证这一点,有必要使密封剂具有良好的流变特性,特别是当它与抗乳腺炎软膏一起使用时。本研究的目的是比较意大利市场上几种乳内密封胶悬浮液的流变行为。为了评价干期乳内悬浮液的流变行为,流变比较方法已经被开发出来。在流变学研究中评估的参数是粘度,3区间触变性测试(3ITT)和材料的粘弹性性质:振幅扫描。此外,为了评估乳内密封剂的密封性能,进行了相容性体外试验,比较了产品单独使用和与两种乳内抗生素悬浮液(Fatroximin和Mastout,均由Fatro S.p.A.生产,并在干燥期使用)接触时的行为。结果表明,当密封胶具有良好的粘度和良好的触变性时,它更有可能留在乳头中,执行其密封作用并阻止病原体的进入。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of the Compatibility between Different Teat Sealants and Intramammary Antimicrobials in Selective Dry Cow Treatment Protocols
The dry period is a crucial time in the lactation cycle, it is the period of highest susceptibility to new infection and the optimum time to cure existing intramammary infection. In selective dry-cow antimicrobial therapy, we have two different ways of intervening in the management treatments of dry period: in the first case there are dairy cows diagnosed healthy, that will be treated only with the teat sealant, in the second, dairy cows with pathogenic mastitis or high cell counts that will receive the intramammary treatment together with the sealant. One of the main prerogative of an intramammary sealant is to ensure that it remains in the teat throughout the dry period. To guarantee this, it is necessary that the sealant is characterized by good rheological properties, especially when it is administered with an antimastitis ointment. The aim of the present study was to compare the rheological behavior of several intramammary sealant suspensions present on the Italian market. To evaluate the rheological behavior of the intramammary suspensions used during the dry period, rheological comparison methods have been developed. The parameters assessed during the rheological study are Viscosity, 3 Interval Thixotropy Test (3ITT) and the viscoelastic nature of materials: Amplitude Sweep. In addition, to evaluate the sealant performance of intramammary sealants, was performed a compatibility in-vitro test, comparing the behavior of the products alone and in contact with two intramammary antibiotic suspensions (Fatroximin and Mastout, both manufactured by Fatro S.p.A. and used during the dry period). The results obtained highlighted that, when a sealant has good viscosity and good thixotropic behavior, is more probable that it remains in the teat, carrying out its sealing action and preventing the entry of pathogens.
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