{"title":"癌症免疫球蛋白的功能作用及其在癌症免疫诊断和免疫治疗中的潜在应用综述","authors":"Alireza Heidari, Victoria Peterson","doi":"10.14419/ijac.v8i1.30500","DOIUrl":null,"url":null,"abstract":"In this research, poly (D, L-lactide-co-glycolide)-block-poly (ethylene glycol), (PLGA-PEG) nanoparticles (NPs) of less than 195 nm in diameter containing of Naringenin (NRG) a naturally flavonoid were synthesized. Encapsulated form NRG improves its medical properties and solubility. The therapeutic efficacy of the encapsulated naringenin (NRG-NPs) and NRG on human lung epithelial (A549) and mouse mammary (4T1) carcinoma cells proliferation was determined by MTT assays. The cytotoxicity potency was rated as follows: NRG-NPs > NRG. The antioxidant effects of the NRG and NRG-NPs were also determined by FRAP method. Our results show that NRG-NPs are cytotoxic compounds for cancer cells and anti-cancer effect can be attributed to the presence of Fe chelatory and antioxidant effects of NRG-NPs. ","PeriodicalId":13723,"journal":{"name":"International Journal of Advanced Chemistry","volume":"88 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2020-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"21","resultStr":"{\"title\":\"A comprehensive review on functional roles of cancerous immunoglobulins and potential applications in cancer immunodiagnostics and immunotherapy\",\"authors\":\"Alireza Heidari, Victoria Peterson\",\"doi\":\"10.14419/ijac.v8i1.30500\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In this research, poly (D, L-lactide-co-glycolide)-block-poly (ethylene glycol), (PLGA-PEG) nanoparticles (NPs) of less than 195 nm in diameter containing of Naringenin (NRG) a naturally flavonoid were synthesized. Encapsulated form NRG improves its medical properties and solubility. The therapeutic efficacy of the encapsulated naringenin (NRG-NPs) and NRG on human lung epithelial (A549) and mouse mammary (4T1) carcinoma cells proliferation was determined by MTT assays. The cytotoxicity potency was rated as follows: NRG-NPs > NRG. The antioxidant effects of the NRG and NRG-NPs were also determined by FRAP method. Our results show that NRG-NPs are cytotoxic compounds for cancer cells and anti-cancer effect can be attributed to the presence of Fe chelatory and antioxidant effects of NRG-NPs. \",\"PeriodicalId\":13723,\"journal\":{\"name\":\"International Journal of Advanced Chemistry\",\"volume\":\"88 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-04-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"21\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Advanced Chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.14419/ijac.v8i1.30500\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Advanced Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14419/ijac.v8i1.30500","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 21
摘要
本研究合成了含天然类黄酮柚皮素(NRG)的直径小于195 nm的聚(D, l -丙交酯-共乙醇酸酯)-嵌段聚乙二醇(PLGA-PEG)纳米颗粒(NPs)。包封后的NRG改善了其医用性能和溶解性。MTT法观察柚皮素包被物(NRG- nps)和NRG对人肺上皮细胞(A549)和小鼠乳腺(4T1)癌细胞增殖的影响。细胞毒效价分级如下:NRG- nps > NRG。采用FRAP法测定NRG和NRG- nps的抗氧化作用。我们的研究结果表明，NRG-NPs是癌细胞的细胞毒性化合物，其抗癌作用可能归因于NRG-NPs的铁螯合和抗氧化作用。
A comprehensive review on functional roles of cancerous immunoglobulins and potential applications in cancer immunodiagnostics and immunotherapy
In this research, poly (D, L-lactide-co-glycolide)-block-poly (ethylene glycol), (PLGA-PEG) nanoparticles (NPs) of less than 195 nm in diameter containing of Naringenin (NRG) a naturally flavonoid were synthesized. Encapsulated form NRG improves its medical properties and solubility. The therapeutic efficacy of the encapsulated naringenin (NRG-NPs) and NRG on human lung epithelial (A549) and mouse mammary (4T1) carcinoma cells proliferation was determined by MTT assays. The cytotoxicity potency was rated as follows: NRG-NPs > NRG. The antioxidant effects of the NRG and NRG-NPs were also determined by FRAP method. Our results show that NRG-NPs are cytotoxic compounds for cancer cells and anti-cancer effect can be attributed to the presence of Fe chelatory and antioxidant effects of NRG-NPs.
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