非达霉素:一种治疗艰难梭菌感染的新型药物

The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien des Maladies Infectieuses et de la Microbiologie Médicale Pub Date : 2015-01-01 DOI:10.1155/2015/934594

G. Zhanel, A. Walkty, J. Karlowsky

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引用次数: 55

摘要

口服万古霉素和口服甲硝唑在治疗艰难梭菌感染(CDIs)方面有一些局限性;然而，口服万古霉素一直被认为是临床试验的金标准。2012年6月，非达霉素获得加拿大卫生部批准用于治疗慢性阻塞性肺病。讨论了其化学、作用机制和药理特性，以及其在CDI治疗中的潜在作用。

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Fidaxomicin: A novel agent for the treatment of Clostridium difficile infection

Oral vancomycin and oral metronidazole have several limitations with regard to their use in the treatment of Clostridium difficile infections (CDIs); however, oral vancomycin has been considered the gold standard in clinical trials. In June 2012, fidaxomicin received Health Canada approval for the treatment of CDIs. Its chemistry, mechanisms of action and pharmacological properties are discussed, along with its potential role in CDI therapy.

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The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien des Maladies Infectieuses et de la Microbiologie Médicale

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