{"title":"茶树黄烷醇类化合物治疗阿尔茨海默病的分子对接与靶点研究","authors":"Nandhini Baskaran, Anitha Subash","doi":"10.21048/ijnd.2022.59.2.29907","DOIUrl":null,"url":null,"abstract":"Alzheimer’s disease is a progressive neurodegenerative disorder with neuropsychiatric symptoms and several cognitive functions and is biochemically characterized by a significant decrease in the brain neurotransmitter acetylcholine. The current study is performed to investigate possible interaction of the active components identified from Camellia sinensis (Green tea) with acetyl cholinesterase (AChE) through docking studies using Schrödinger software (Maestro V: 11.8 Schrödinger_suite-2019). In silico study results clearly showed that catechin and epicatechin-3-gallate binds effectively with AChE through strong hydrogen bonding","PeriodicalId":22457,"journal":{"name":"The Indian journal of nutrition and dietetics","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Molecular Docking and Therapeutic Targets of Flavanol Compounds from Camellia sinensis on Alzheimer’s Disease\",\"authors\":\"Nandhini Baskaran, Anitha Subash\",\"doi\":\"10.21048/ijnd.2022.59.2.29907\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Alzheimer’s disease is a progressive neurodegenerative disorder with neuropsychiatric symptoms and several cognitive functions and is biochemically characterized by a significant decrease in the brain neurotransmitter acetylcholine. The current study is performed to investigate possible interaction of the active components identified from Camellia sinensis (Green tea) with acetyl cholinesterase (AChE) through docking studies using Schrödinger software (Maestro V: 11.8 Schrödinger_suite-2019). In silico study results clearly showed that catechin and epicatechin-3-gallate binds effectively with AChE through strong hydrogen bonding\",\"PeriodicalId\":22457,\"journal\":{\"name\":\"The Indian journal of nutrition and dietetics\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-05-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Indian journal of nutrition and dietetics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.21048/ijnd.2022.59.2.29907\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Indian journal of nutrition and dietetics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21048/ijnd.2022.59.2.29907","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Molecular Docking and Therapeutic Targets of Flavanol Compounds from Camellia sinensis on Alzheimer’s Disease
Alzheimer’s disease is a progressive neurodegenerative disorder with neuropsychiatric symptoms and several cognitive functions and is biochemically characterized by a significant decrease in the brain neurotransmitter acetylcholine. The current study is performed to investigate possible interaction of the active components identified from Camellia sinensis (Green tea) with acetyl cholinesterase (AChE) through docking studies using Schrödinger software (Maestro V: 11.8 Schrödinger_suite-2019). In silico study results clearly showed that catechin and epicatechin-3-gallate binds effectively with AChE through strong hydrogen bonding
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