Attempt to Reduce Potentially Flammable Organic Solvents in Chemical Synthesis

A fire sometimes ignited an organic solvent in a chemical laboratory. A mechanochemical synthesis may be a good way to reduce the amount of organic solvents or without organic solvents compared to conventional synthesis in solutions. The solvent affected the product, namely solvent methanol acted as a ligand, although the quality of the data of X-ray crystallography is usually difficult to report in a strict research article in the case of our Azo-Schiff base metal complexes. Thus substitution of synthesis methods associated with potentially dangerous organic solvents may be possible depending on the application or purpose.