Defining the best candidates for testosterone replacement?

It is widely known that re-establishing physiologic levels of testosterone in symptomatic men with testosterone deficiency (TD) improves the undesirable symptoms associated with low testosterone. The indications for testosterone replacement therapy (TRT) have been evolving as research continues to find out who are the best candidates for therapy. Recently, concerns on the association of TRT and cardiovascular disease have received considerable attention. Before this, considerable attention had focused on the potential dangers of TRT and the risk of prostate cancer. The vast majority of contemporary evidence suggests that men with treated prostate cancer and no evidence of active disease are appropriate candidates for TRT in the context of symptomatic TD. Further, current evidence does not support denying TRT to symptomatic men with TD based on stable cardiac disease.