天冬酰胺酶诱导的急性坏死性胰腺炎导致急性淋巴细胞白血病成人慢性胰腺炎和假性囊肿

The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Pub Date : 2023-04-10 DOI:10.24871/241202398-101

R. Adiwinata, B. J. Waleleng, H. Haroen, Linda Rotty, Fandy Gosal, Luciana Rotty, Cecillia Hendratta, P. Lasut, Jeanne Winarta, Andrew Waleleng, M. Tendean

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引用次数: 0

摘要

天冬酰胺酶是急性淋巴细胞白血病(ALL)治疗的主要化疗方案之一。急性胰腺炎是l-天冬酰胺酶治疗的严重副作用之一，可能导致化疗周期中断。假性囊肿和慢性胰腺炎的长期并发症可能是毁灭性的。天冬酰胺酶引起的胰腺炎在成人中是罕见的，因为ALL的性质通常发生在儿童人群中。天冬酰胺酶诱发胰腺炎的病理生理机制尚不清楚。我们报告一位18岁男性急性急性胰腺炎合并天冬酰胺酶诱发急性坏死性胰腺炎并发慢性胰腺炎和假性囊肿。

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Asparaginase-Induced Acute Necrotizing Pancreatitis Resulting in Chronic Pancreatitis and Pseudocyst in an Adult with Acute Lymphocytic Leukemia

L-Asparaginase is one of the main chemotherapy regiments for acute lymphocytic leukemia (ALL) management. Acute pancreatitis is one of the serious side effects of l-asparaginase administration and may lead to interruption of chemotherapy cycle. Long term complications may be devastating for patients which include of pseudocyst pancreas and chronic pancreatitis. Asparaginase induced pancreatitis is rare among adult due to the nature of ALL which commonly occurred in children population. The pathophysiology of asparaginase induced pancreatitis is still unclear. Here we present 18-year-old male with ALL and asparaginase induced acute necrotizing pancreatitis which complicated to chronic pancreatitis and pseudocyst.

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来源期刊

The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy

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审稿时长

8 weeks