A MULTIFACTORIAL IMPACT ON RESPIRATORY MORBIDITY IN PEOPLE OF REPRODUCTIVE AGE AND EFFECTIVENESS OF NATOPHERINE- AND ANDROPHERINE-CONTAINING ODORANTS REGARDING A NON-SPECIFIC RESISTANCE OF THE NASAL MUCOSA AND LOWERED MORBIDITY OF RESPIRATORY INFECTIONS

Prevention of respiratory infections during epidemic periods is an important task of modern health care in Russia and the world. One such approach may be the use of volatile substances capable of activating nonspecific resistance of the nasal mucosa. Long-term application of synthetic analogues of female pheromones to young men leads to a decrease in the frequency of respiratory diseases, an increase in the levels of secretory immunoglobulins, and in persons with allergic diseases, to a decrease in the levels of eosinophilia in the peripheral blood. Based on this, the aim of the study was set - to study the influence of catamnesis factors and indicators reflecting the functioning of the mucosal immunity of the nasal mucosa, its nonspecific resistance, on the formation of frequent respiratory morbidity; as well as to evaluate the effectiveness of odorants with natopherine and andropherine in relation to the dynamics of these indicators and to reduce the frequency of respiratory infections in young people. Materials and methods. A survey of 46 conditionally healthy boys and girls, in the age range from 18 to 22 years, was carried out. The frequency of respiratory morbidity, catamnesis factors, and the results of non-invasive studies (cytokine concentrations in the nasopharyngeal aspirate and rhinocytograms). Within 30 days, all young people were applied to the nasolabial fold synthetic analogues of male (andropherine) and female (natopherine) pheromones (andropherine for young woman, natopherine for young man). A re-examination with the above mentioned studies was carried out on the 14th and 30th day of the experiment. The frequency of respiratory infections was reassessed one year after the start of the experiment. Results. The study showed a number of predictors and protectors of frequent and long-term respiratory morbidity in young people. The predictors of this condition were catamnestics markers of allergic anomalies of the constitution, behavioral factors (smoking), as well as immune indicators of allergy (IL-4) and mucociliary clearance deficiency. A monthly course of applications on the skin of the nasolabial fold of odorants based on synthetic analogues of male and female pheromones (steranes) has a positive effect both on the nonspecific resistance of the nasal mucosa, on the immune parameters of its functioning. After a month of using steranes, complete decontamination of the nasal mucosa from coccal microorganisms occurs. A year after the experiment, there are no frequently and long-term ill young people. This indicates a significant clinical effect of the applied odorants.