麻豆水提取物对烟酰胺-链脲佐菌素诱导的糖尿病大鼠的降糖作用

R. J. I., R. R.
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摘要

本研究探讨了麻豆水提物(ASEMP)对烟酰胺-链脲佐菌素诱导的Wistar大鼠糖尿病胰腺内分泌区的治疗作用。两种麻瓜的抗高血糖作用对IIHR选择3和Arka Dhanvantari进行了研究。与对照组(格列苯脲5 mg/kg)、糖尿病对照组(248±0.3 mg/dl)和正常对照组(90±0.3 mg/dl)相比,口服ASEMP对烟酰胺-链状佐菌素诱导的糖尿病大鼠血糖水平(94±0.2 mg/dl ASEMP 400 mg/kg)有降糖作用。ASEMP对烟酰胺-链脲佐菌素诱导的糖尿病大鼠肌酐水平也有显著降低。胰腺内分泌区组织病理学检查显示,糖尿病- asemp治疗大鼠胰岛细胞恢复,与糖尿病对照组相比,β细胞体积增加,坏死改变明显减少。因此,本研究支持并建议探索花楸水提取物作为治疗2型糖尿病的替代药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Anti-hyperglycemic Efficiency of the Aqueous Seed Extract of Mucuna pruriens in Nicotinamide-Streptozotocin-induced Diabetic Wistar Rats
This study was undertaken to evaluate the remedial effect of the aqueous seed extract of Mucuna pruriens (ASEMP) on the endocrine region of pancreas of nicotinamide-streptozotocin-induced diabetes in Wistar rats. The anti-hyperglycemic efficiency of two varieties of Mucuna pruriens var utilis; IIHR Selection 3 and Arka Dhanvantari was investigated. Oral administration of ASEMP against the nicotinamide-streptozotocin-induced diabetes in the Wistar rats showed anti-hyperglycemic effect on the blood glucose level (94 ± 0.2 mg/dl ASEMP 400 mg/kg) when compared with the control group (92 ± 0.2 mg/dl glibenclamide 5 mg/kg), (248 ± 0.3 mg/dl Diabetic control) and (90 ± 0.3 mg/dl Normal control). Significant reduction in creatinine level of the nicotinamide-streptozotocin-induced diabetic rats treated with ASEMP was also recorded. Histopathology examination of the endocrine region of pancreas of the rats revealed restoration of pancreatic islet cells in the diabetic-ASEMP treated rats as the beta cell mass increased and necrotic changes was reduced significantly in contrast with the diabetic control group which showed degenerated pancreatic islet cells. Therefore, this study supports and recommends the exploration of the aqueous seed extract of M. pruriens as an alternative medicine for the management of type-2 diabetes.
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