三个月剂量的皮质类固醇脉冲治疗产生满意的,但暂时的反应严重斑秃患者

IF 2.3 4区 医学 Q2 DERMATOLOGY
Heng-An Lu, Chao-Chun Yang, Yu-Chen Chen
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引用次数: 1

摘要

斑秃(AA)是一种常见的无疤痕型脱发,在某些情况下会导致慢性和严重的脱发。虽然皮质类固醇脉冲疗法的使用尚无标准的既定方案,但据报道,对于严重AA患者来说,它是一种有效且耐受性良好的治疗选择。本研究回顾性分析了2010年1月至2020年12月诊断为严重AA(>50%脱发)的29例患者,并接受了每月3次静脉注射皮质类固醇的治疗。甲强的松龙(500 mg/天)在第一次疗程中连续3天给予,随后在第二次和第三次疗程中给予1天的治疗方案。治疗总有效率为58.6%,完全有效率为13.8%。13例获得满意反应的患者中有11例复发。亚组分析显示,AA持续时间较短(≤6个月)的患者对皮质类固醇脉冲治疗的反应明显更好。本研究强调,3个月的皮质类固醇治疗足以引起满意但暂时的反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Three monthly doses of corticosteroid pulse therapy yields a satisfactory but temporary response in severe alopecia areata patients
Alopecia areata (AA) is a common, nonscarring type of alopecia that can cause chronic and severe hair loss in some cases. Although there is no standard established protocol for the use of corticosteroid pulse therapy, it has been reported to be an effective and well-tolerated treatment option for patients with severe AA. This study retrospectively analyzed 29 patients who were diagnosed with severe AA (>50% hair loss) from January 2010 to December 2020 and treated with 3 monthly sessions of intravenous corticosteroids. Methylprednisolone (500 mg/day) was administered for 3 consecutive days during the first session, followed by a 1-day treatment regimen for the second and third sessions. The treatment had an overall satisfactory response rate of 58.6% and a complete response rate of 13.8%. Eleven of the 13 patients who achieved a satisfactory response experienced relapse. A subgroup analysis showed that patients with a shorter duration of AA (≤6 months) had a significantly better response to corticosteroid pulse therapy. This study highlights that 3 monthly sessions of corticosteroid therapy are sufficient to induce satisfactory but temporary response.
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来源期刊
Dermatologica Sinica
Dermatologica Sinica DERMATOLOGY-
CiteScore
2.80
自引率
20.00%
发文量
28
审稿时长
>12 weeks
期刊介绍: Dermatologica Sinica aims to publish high quality scientific research in the field of dermatology, with the goal of promoting and disseminating dermatological-related medical science knowledge to improve global health. Articles on clinical, laboratory, educational, and social research in dermatology and other related fields that are of interest to the medical profession are eligible for consideration. Review articles, original articles, brief reports, case reports and correspondence are accepted.
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