金属支架植入术治疗冠状动脉分叉疗效的计算与预测

Xiaotong Yan, Kai Yue, Xinxin Zhang
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引用次数: 0

摘要

了解血流特征行为,对于探索动脉粥样硬化(AS)的形成机制和过程,掌握AS的发病机制,为临床治疗提供有效的理论指导具有重要意义。为预测斑块对血流动力学的影响及支架介入治疗狭窄动脉的治疗效果,基于COMSOL软件,构建有狭窄、无狭窄和有支架的冠状动脉分叉模型,采用流固相互作用法分析3例患者血流动力学特征。在这些研究中获得了冠状动脉的动态速度、流线、压力、Von Mises应力和位移分布。结果表明,斑块的速度急剧增加,斑块的周围组织因较高的应激而更容易发生损伤的风险。支架动脉内血流速度趋于稳定,流速分布均匀,说明支血管的血供进一步改善,有利于正常血供和血流稳定。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Computation Prediction of the Therapeutic Effect of Metal Stent Implantation for Coronary Bifurcation
A good understanding of the characteristics behavior of blood flow is significant for exploring the formation mechanism and process of atherosclerosis (AS), grasping the pathogenesis of AS, and providing effective theoretical guidance for clinical treatment of AS. To predict the influence of plaque on hemodynamics and the therapeutic effect of stent interventional treatment on stenosis artery, the coronary bifurcation models with/without stenosis and with stent implantation were constructed to analyze the hemodynamic characteristics in three cases using fluid-solid interaction method based on COMSOL software. The dynamic velocity, streamline, pressure, Von Mises stress, and displacement distributions in the coronary artery were obtained in these studies. Results show that the velocity of the plaque increased sharply, and the peripheral tissues of the plaque are more prone to the risk of injury because of the higher stress. The blood flow velocity tends to be stable in the stented artery and the velocity distribution is uniform, indicating that the blood supply of branch vessels is further improved, which is conducive to the normal blood supply and stable blood flow.
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