慢性牙周炎患者血浆去除术治疗期间口腔内皮的功能活性

Q4 Immunology and Microbiology
A. A. Fefelov, N. Tsybikov, L. Sholokhov, E. Fefelova
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引用次数: 0

摘要

慢性牙周炎作为一种口腔骨免疫性疾病,伴随着内皮细胞功能活性的改变。此外,异常血管化加剧了牙周炎症,因为它促进了大量免疫活性细胞的迁移,炎症介质和细胞因子的涌入。我们的工作的目的是研究慢性牙周炎患者口腔血管内皮细胞的功能活性在血浆修复治疗中的作用。材料和方法。研究对象为30例35岁(32.50;40.00)岁,无严重躯体病理(主要组)。对照组20例,年龄38岁(34.00;45.00岁,口腔无炎性疾病。所有患者均接受局部抗炎治疗和牙周袋卫生、矫正咬合接触、刮除、血浆提升。测定口服液中可溶性黏附分子ICAM-1、VCAM-1、内皮素-1的浓度、微生物群的定性和定量组成。在血浆移植治疗后,观察到炎症过程的活性明显减轻。在慢性牙周炎患者中,100%的病例发现牙龈卟啉单胞菌,滴度为5.73 (4.9;6.7) lg (gEq/样品),在62.5% -普雷沃氏菌培养基中滴度为4.5 (3.0;5.5) lg (gEq/样品)。在治疗的背景下,观察到微生物的发生和微生物数量的减少。慢性牙周炎患者口腔液中可溶性形态VCAM-1的浓度分别是对照组的38.3倍(p = 0.000001)和18.1倍(p = 0.00001)。在血浆提升治疗的背景下,研究物质的水平有所下降,但分别超过对照组的25.2倍和6.4倍。牙周炎患者口腔液内皮素含量比健康人高出40.7% (p = 0.003),治疗期间内皮素含量有所下降,但未达到健康人水平(p = 0.04)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Functional activity of the oral endothelium in persons, with chronic periodontitis during treatment with plasmolifting
Chronic periodontitis as an osteoimmune disease of the oral cavity is accompanied by a change in the functional activity of endotheliocytes. Moreover, abnormal vascularization exacerbates periodontal inflammation, as it promotes the transmigration of a larger number of immunocompetent cells, the influx of inflammatory mediators and cytokines.The aim of our work was to study the functional activity of the endothelium of the vessels of the oral cavity in persons suffering from chronic periodontitis in the treatment of plasmolifting.Materials and methods. Under observation were 30 patients diagnosed with chronic generalized periodontitis of moderate severity at the age of 35 (32.50; 40.00) years, with no severe somatic pathology (main group). The comparison group included 20 people aged 38 (34.00; 45.00) years with no inflammatory diseases in the oral cavity. All patients underwent local anti-inflammatory therapy and sanitation of periodontal pockets, correction of occlusal contacts, curettage, plasma lifting. Oral fluid concentration of soluble adhesion molecules ICAM-1 and VCAM-1, endothelin-1, qualitative and quantitative composition of microflora were determined.Results. After the treatment with plasmolifting, a noticeable relief of the activity of the inflammatory process was observed. In patients with chronic periodontitis, Porphyromonas gingivalis was found in 100 % of cases in a titer of 5.73 (4.9; 6.7) lg (gEq/sample), in 62.5 % – Prevotella intermedia in a titer of 4.5 (3.0; 5.5) lg (gEq/sample). Against the background of therapy, decrease of the occurrence of the microorganism and of the number of microorganisms was observed. The concentration of the soluble form of VCAM-1 in the oral fluid of patients with chronic periodontitis exceeded the values of the control group by 38.3 times (p = 0.000001), and ICAM-1 – by 18.1 times (p = 0.00001). Against the background of plasmolifting therapy, the level of the studied substances decreased, but exceeded the control values by 25.2 and 6.4 times, respectively. The content of endothelin in the oral fluid in patients with periodontitis exceeded the values of healthy individuals by 40.7 % (p = 0.003), during therapy its values decreased, but did not reach the level of healthy volunteers (p = 0.04).
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来源期刊
Acta Biomedica Scientifica
Acta Biomedica Scientifica Immunology and Microbiology-General Immunology and Microbiology
CiteScore
0.40
自引率
0.00%
发文量
106
审稿时长
7 weeks
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