涡虫的先天免疫和内在免疫

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2017-11-04 DOI:10.25431/1824-307X/ISJ.V14I1.443-452

Lili Gao, Ao Li, Na Li, Xi Liu, Hongkuan Deng, Bosheng Zhao, Qiuxiang Pang

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引用次数: 4

摘要

扁蠕虫门的涡虫具有特殊的系统发育地位和较强的成体组织再生能力，引起了人们的广泛关注。涡虫自然暴露于各种病原体(微生物和有害化学物质)，但通常能在这些挑战中生存下来。因此，这些动物可以为先天免疫系统的进化提供有用的见解。本文主要对涡虫的免疫组织(表皮、咽、肠)、免疫细胞(吞噬网状细胞)和免疫基因进行综述。此外，我们提供了先天免疫系统中的关键蛋白质的概述-例如，模式识别受体，补体系统蛋白，抗微生物肽和抗氧化酶。特别是，在涡虫感染激活的信号通路的效应进行了综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Innate and intrinsic immunity in planarians

Planarians in the Phylum Platyhelminthes occupy a peculiar phylogenetic position and have a strong regenerative capacity of their adult tissues, which has aroused general attention. Planarians are spontaneously exposed to various pathogens (microbes and harmful chemicals), but typically survive these challenges. Therefore, these animals can provide useful insights into the evolution of the innate immune system. This review mainly focuses on immune tissues (epidermis, pharynx, and intestine), immune cells (phagocytic reticular cells) and immune genes of planarians. In addition, we provide an overview of the critical proteins in the innate immune system - for example, pattern recognition receptors, complement system proteins, anti-microbial peptides and antioxidant enzymes. In particular, the effectors of the signaling pathways activated upon planarian infection are reviewed.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.