硒:化学生物学、毒理学和放射防护

K. Priyadarsini, B. Singh, A. Kunwar
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引用次数: 1

摘要

硒是一种微量营养素,也是谷胱甘肽过氧化物酶(GPx)和硫氧还蛋白还原酶(TrxR)等重要氧化还原酶的活性成分,在过去的四五十年里,世界各地的研究人员对硒进行了广泛的研究。无机和有机硒化合物正在被评估为许多病毒感染和癌症等慢性疾病的可能药物或佐剂。一些癌症患者的临床试验已经证实,补充硒有助于从癌症治疗相关的副作用中恢复,硒本身不会干扰癌症治疗。人们正在努力开发具有抗癌特性的新型硒化合物。本文将讨论这些方面。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Selenium: Chemical biology, toxicology and radioprotection
Selenium, a micronutrient and an active constituent of important redox enzymes like glutathione peroxidase (GPx) and thioredoxin reductase (TrxR), has been investigated extensively by researchers all over the world for the last four to five decades. Both inorganic and organic selenium compounds are being evaluated as probable drugs or adjuvants for many viral infections and chronic diseases like cancer. Several clinical trials in cancer patients have confirmed that selenium supplementation helps in recovering from cancer therapy associated side effects and selenium itself does not interfere in cancer therapy. Efforts are on to develop new selenium compounds with anti-cancer properties. These aspects will be discussed in this article.
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