Changing Prevalence of Gastric Fundic Gland Polyps: Current Scenario in North India.

Introduction: The prevalence and histopathological type of gastric polyp vary between populations. In the recent past aggressive treatment of Helicobacter pylori (H. pylori) and the excessive use of proton pump inhibitors (PPIs) have altered the prevalence of specific types of gastric polyp. This study was designed to evaluate the prevalence and histopathology background of gastric mucosa in cases with fundic gland polyps (FGP). Material and Methods: The medical record of patients who underwent esophagogastroduodenoscopy in 2 centers in Northern India from 2011-2018 were reviewed. Results: The prevalence of gastric polyps was 5%, of which 900 (50%) were fundic gland polyps (FGP). Mean age of presentation was 51.42 years, 70% were located in fundus/ corpus, 62% had dyspepsia, chronic inactive gastritis (CIG) was present in 60%, 95% were multiple and 27% were more than 1cm in size. Conclusions: As a result of anti H. pylori treatment and the excessive use of PPIs, FGP are most common in Northern India. CIG, H. pylori gastritis and Intestinal metaplasia were seen in gastric histology of the cases. These results are interesting and provide new perspective to look for pathogenesis of gastric polyps.