巴基斯坦COVID-19的症状和关联:单中心描述性研究

Shehrbano Ali
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摘要

简介:由于SARS-CoV2是一种新型病毒,以前对这种疾病知之甚少,但最近的研究表明,它通过飞沫感染传播,主要影响呼吸道,引起发烧、疲劳和呼吸短促等症状。合并症增加严重疾病的风险。目的和目的:我们的研究旨在确定巴基斯坦COVID-19的主要表现和相关性。研究地点和时间:该研究于2020年6月1日至2020年6月10日在拉合尔CMH进行,为期10天。材料与方法:采集新冠肺炎确诊病例107例。由主治医生对参与者进行问卷调查,询问他们的症状、并发症的存在和合并症。数据采用SPSS 25.0进行分析。p值<0.05为显著性。结果:男性77.6%,女性22.4%,平均年龄40.68岁。常见症状为发热(71%)、咳嗽(32.7%)、喉咙痛(36.4%)和肌痛(57%)。36名参与者进展为并发症,最常见的是肺炎(22.4%)。参与者的年龄与发热(p= 0.017)、呼吸短促(p= 0.048)和疲劳(p= 0.021)以及肺炎并发症(p= 0.001)的症状显著相关。合并症与许多症状和并发症相关,最显著的心血管疾病与急性肾损伤(p= 0.002)、心力衰竭(p= 0.005)和中风(p= 0.005)等并发症的发生相关。结论:COVID-19的症状主要是呼吸道症状,但病毒也会影响胃肠道、神经元、心脏等其他器官。年龄和合并症的存在增加了患更严重疾病的风险,有心血管疾病史的患者发生并发症的风险最高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Symptoms and Associations of COVID-19 in Pakistan A Single Centre, Descriptive Study
Introduction: Since SARS-CoV2 is a novel virus, not much was previously known about the disease, however recent studies have shown that it is transmitted via droplet infection and mainly affects the respiratory tract, causing symptoms of fever, fatigue and shortness of breath. Comorbidities increase risk of severe disease. Aims & Objectives: Our study aims to determine the predominant manifestations and correlations of COVID-19 in Pakistan. Place and duration of study: The study was carried out at CMH Lahore over ten-day duration from 1st June 2020 to 10th June 2020. Material & Methods: Samples of 107 confirmed cases of COVID-19 was taken. Participants were administered a questionnaire by attending doctor which enquired regarding their symptoms, presence of complications, and comorbidities. Data was analyzed using SPSS 25.0. A p-value of <0.05 was considered significant. Results: 77.6% of participants were male whereas 22.4% were female, with mean age 40.68 years. Symptoms commonly experienced were fever (71%), cough (32.7%), sore throat (36.4%), and myalgia (57%). Progression to complications was seen in 36 participants, most common being pneumonia (22.4%). Age of participants was significantly associated with symptoms of fever (p= 0.017), shortness of breath (p= 0.048) and fatigue (p= 0.021), and complication of pneumonia (p= 0.001). Comorbidities were associated with many symptoms and complications, most prominently cardiovascular disease was associated with development of complications like acute kidney injury (p= 0.002), cardiac failure (p= 0.005), and stroke (p= 0.005). Conclusion: Symptoms of COVID-19 are respiratory in nature primarily, however, the virus also affects other organs like gastrointestinal tract, neurons, heart. Age and presence of comorbidities increase risk of getting more severe disease, with highest risk of complications occurring in patients with history of cardiovascular disease.
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