急性心肌梗死患者血清miR-499及性别决定区Y-box 6表达与预后的关系

IF 0.5 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
Jing Mao, Bin Wang, Yingjia Li
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引用次数: 1

摘要

摘要背景:探讨急性心肌梗死(AMI)患者行经皮冠状动脉介入治疗(PCI)后血清miR-499及性别决定区Y-box 6 (SOX6)表达与主要心脑血管不良事件(MACCE)及预后的关系。方法:收集2016年2月至2019年10月诊断的132例患者的临床资料。RT-qPCR检测血清miR-499和SOX6的表达。根据受试者工作特征曲线确定最佳截断值,将患者分为miR-499低表达组和高表达组,SOX6高表达组和低表达组。采用Kaplan-Meier法绘制生存曲线,采用多因素logistic回归分析探讨MACCE的独立危险因素。基于各因素建立了nomogram模型,并利用内部数据进行了验证。结果:AMI组miR-499表达高于对照组,SOX6表达低于对照组(P<0.05)。PCI后miR-499表达降低,SOX6表达升高(P<0.05)。miR-499低表达组3年生存率和MACCE-free率高于miR-499高表达组(P<0.05)。SOX6低表达组3年生存率和MACCE-free率低于SOX6高表达组(P<0.05)。AMI病史、LVEF、CK-MB、miR-499、SOX6表达是MACCE的独立危险因素(P<0.05)。nomogram模型预测总生存期的准确度较高,一致性指数为0.742 (95%CI=0.684-0.845)。结论:AMI患者血清miR-499表达升高,SOX6表达降低。miR-499高表达是预后不良的独立危险因素。所建立的nomogram模型可用于预测PCI术后MACCE的发生风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Associations of serum expressions of miR-499 and sex determining region Y-box 6 with prognosis of acute myocardial infarction patients
Abstract Background: To explore the associations of serum expressions of miR-499 and sex determining region Y-box 6 (SOX6) with major adverse cardiovascular and cerebrovascular events (MACCE) and prognosis of acute myocardial infarction (AMI) patients undergoing percutaneous coronary intervention (PCI). Methods: The clinical data of 132 patients diagnosed from February 2016 to October 2019 were collected. Serum miR-499 and SOX6 expressions were detected by RT-qPCR. Optimal cut-off values were determined using receiver operating characteristic curves, based on which patients were divided into low and high miR-499 expression groups, and high and low SOX6 expression groups. Survival curves were plotted using Kaplan-Meier method, and the independent risk factors for MACCE were explored by multivariate logistic regression analysis. A nomogram model was established based on the factors and validated using internal data. Results: AMI group had higher miR-499 expression and lower SOX6 expression than those of control group (P<0.05). After PCI, miR-499 expression decreased and SOX6 expression increased (P<0.05). Low miR-499 expression group had higher 3-year survival and MACCE-free rates than those of high miR-499 expression group (P<0.05). Low SOX6 expression group had lower 3-year survival and MACCE-free rates than those of high SOX6 expression group (P<0.05). AMI history, LVEF, CK-MB, miR-499 and SOX6 expressions were independent risk factors for MACCE (P<0.05). The nomogram model had high accuracy for predicting overall survival, with a concordance index of 0.742 (95%CI=0.684-0.845). Conclusions: AMI patients have increased serum expression of miR-499 and decreased expression of SOX6. High miR-499 expression is an independent risk factor for poor prognosis. The established nomogram model can be used to predict the risk of MACCE after PCI.
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来源期刊
Revista Romana De Medicina De Laborator
Revista Romana De Medicina De Laborator MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
0.31
自引率
20.00%
发文量
43
审稿时长
>12 weeks
期刊介绍: The aim of the journal is to publish new information that would lead to a better understanding of biological mechanisms of production of human diseases, their prevention and diagnosis as early as possible and to monitor therapy and the development of the health of patients
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