土壤放线菌链霉菌(Streptomyces sp. R1706-8)中的红霉素H

Journal of Chemical Research-s Pub Date : 2022-07-01 DOI:10.1177/17475198221109161

Guoli Li, Huijing Qi, Yigang He, Yu-Kai Shen, Tong Shen

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引用次数: 0

摘要

该放线菌菌株R1706-8从角面蜂(Osmia cornifrons)巢穴土壤样品中分离得到，经16SrRNA序列分析鉴定为Streptomyces sp.。通过红外分析、高分辨率电喷雾质谱分析、一维和二维核磁共振谱分析以及与文献数据的比较，对固体发酵得到的两种康那霉素衍生物进行了鉴定。在这两个衍生物中，一个是新化合物，命名为concanamycin H，另一个是已知的化合物，concanamycin G。这两个化合物的抗菌活性进行了测试，concanamycin H和G对枯草芽孢杆菌具有抑制活性(最小抑制浓度为0.625µG mL−1)。

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Concanamycin H from the soil actinomycete Streptomyces sp. R1706-8

The actinomycete strain R1706-8 is isolated from a soil sample collected from the nest of the horned-face bee (Osmia cornifrons) and identified as Streptomyces sp. based upon the results of 16SrRNA sequence analysis. Two concanamycin derivatives obtained from the solid fermentation have been determined by analysis of the infrared, high-resolution electrospray ionization mass spectrometry, 1D and 2D NMR spectra as well as by comparison with literature data. Of the two derivatives, one is a new compound, named concanamycin H, and the other is the known compound, concanamycin G. These compounds are assayed for antibacterial activity, with concanamycins H and G displaying inhibitory activity against Bacillus subtilis (minimum inhibitory concentration = 0.625 µg mL−1).

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来源期刊

Journal of Chemical Research-s 化学科学, 有机化学, 有机合成

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： The Journal of Chemical Research is a peer reviewed journal that publishes full-length review and research papers in all branches of experimental chemistry. The journal fills a niche by also publishing short papers, a format which favours particular types of work, e.g. the scope of new reagents or methodology, and the elucidation of the structure of novel compounds. Though welcome, short papers should not result in fragmentation of publication, they should describe a completed piece of work. The Journal is not intended as a vehicle for preliminary publications. The work must meet all the normal criteria for acceptance as regards scientific standards. Papers that contain extensive biological results or material relating to other areas of science may be diverted to more appropriate specialist journals. Areas of coverage include: Organic Chemistry; Inorganic Chemistry; Materials Chemistry; Crystallography; Computational Chemistry.