预防精神分裂症首发复发:2EPs项目,背景,理论基础和研究设计

IF 5.2 3区 医学 Q1 PSYCHIATRY
Miguel Bernardo , Silvia Amoretti , Manuel Jesús Cuesta , Mara Parellada , Gisela Mezquida , 2EPs Group , The acronym 2EPs Group responds to the authorship of the principal investigators of the fifteen centres that have participated in this coordinated multicenter project, Ana González-Pinto , Daniel Bergé , Antonio Lobo , Eduardo J. Aguilar , Judith Usall , Iluminada Corripio , Julio Bobes , Roberto Rodríguez-Jiménez , Salvador Sarró , Fernando Contreras , Ángela Ibáñez , Miguel Gutiérrez , Juan Antonio Micó
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引用次数: 12

摘要

高达80%的首发精神病患者在缓解后的五年内复发。鉴于对患者和家属的潜在危害,复发应成为预防的重点。它有可能破坏他们的心理社会康复,增加对治疗的抵抗风险,并给社会带来更大的直接和间接成本。基于先前一个名为“基因型-表型和环境”的项目。“首次精神病发作预测模型的应用”(pep项目),“精神分裂症第二次发作的临床和神经生物学决定因素”项目。“首次精神病发作的纵向研究”被设计,也被称为2EPs项目。它旨在识别和描述那些预测首次发作后几年内复发的因素。该项目的重点是跟踪临床过程,进行神经心理学评估、生物学和神经解剖学测量、遗传依从性和身体健康监测,以便将第二次发作的患者亚组与另一组仍处于缓解期的患者进行比较。本文的主要目的是描述2EPs项目的基本原理,解释所采用的测量方法,并提供所选择的临床和功能测量的概述。2EPs项目是一项多中心、协调、自然、纵向随访研究,研究对象为西班牙精神分裂症首次精神病发作后缓解的患者样本,为期三年。它正在密切监测所招募病例的临床病程,以比较第二次发作的患者亚组和仍处于缓解期的患者亚组。样本由西班牙15个临床中心招募的223名受试者组成,这些受试者具有先前pep研究项目的经验,尽管2EPs是生物研究中新的基本组的扩展版本。在招募的总样本中,63例患者出现复发(44%)。2EPs的出现以详尽、新颖和多模式的方式描述了首次发作的特征,从而有助于复发预测模型的发展。确定复发患者的特征可以提高早期发现和干预。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The prevention of relapses in first episodes of schizophrenia: The 2EPs Project, background, rationale and study design

Up to 80% of first-episode psychosis patients suffer a relapse within five years of the remission. Relapse should be an important focus of prevention given the potential harm to the patient and family. It threatens to disrupt their psychosocial recovery, increases the risk of resistance to treatment and has been associated with greater direct and indirect costs for society.

Based on a previous project entitled “Genotype–phenotype and environment. Application to a predictive model in first psychotic episodes” (PEPs Project), the project “Clinical and neurobiological determinants of second episodes of schizophrenia. Longitudinal study of first episode of psychosis” was designed, also known as the 2EPs Project. It aimed to identify and characterize those factors that predict a relapse within the years immediately following a first episode. This project has focused on following the clinical course, with neuropsychological assessments, biological and neuroanatomical measures, genetic adherence and physical health monitoring in order to compare a subgroup of patients with a second episode to another group of patients which remains in remission. The main objective of the present article is to describe the rationale of the 2EPs Project, explaining the measurement approach adopted and providing an overview of the selected clinical and functional measures.

2EPs Project is a multicenter, coordinated, naturalistic, longitudinal follow-up study over three years in a Spanish sample of patients in remission after a first-psychotic episode of schizophrenia. It is closely monitoring the clinical course of the cases recruited to compare the subgroup of patients with a second episode to that which remains in remission. The sample is composed of 223 subjects recruited from 15 clinical centres in Spain with experience of the preceding PEPs Study project, albeit 2EPs being an expanded version with new basic groups in biological research. From the total sample recruited, 63 patients presented a relapse (44%).

2EPs arose to characterize first episodes in an exhaustive, novel and multimodal way, thus contributing towards the development of a predictive model of relapse. Identifying the characteristics of patients who relapse could improve early detection and intervention.

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来源期刊
自引率
3.30%
发文量
58
期刊介绍: The Spanish Journal of Psychiatry and Mental Health (SJPMH), incorporated into ISSN 1888-9891, is the official scientific publication of the Spanish Society of Psychiatry and Mental Health. The journal focuses on studying mental illnesses, their pathological processes, and their psychosocial consequences, and aims to disseminate scientific advances in all areas related to mental health and illness. SJPMH accepts unpublished works on psychiatry and mental health, including their medical and social implications. The journal provides space for research in the biological, clinical, and psychosocial fields. Manuscripts undergo peer-review by external reviewers before being accepted for publication. SJPMH is indexed in Index Medicus/Medline, IBECS, Social Sciences Citation Index Journal Citation Reports/Social Sciences Edition, and Current Contents/Social and Behavioral Sciences.
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