筛选新型抗病毒药物的技术平台

R. Lara, Diana Marcela Buitrago Ramírez
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引用次数: 0

摘要

病毒的主要特征之一是其高度遗传多样性,产生与抗病毒药物耐药性相关的突变的病毒变体,导致治疗失败,增加发病率和死亡率,降低受感染个体的质量和预期寿命。这就是为什么需要找到新的替代办法,在最强大和最有效的手段中接受变化。现代药理学设计可以通过技术平台以更快、更便宜和更有效的方式进行,从而提供在宿主-病毒结合位点起作用的新的有前途的化合物。在这篇综述中,我们描述了开发新的抗病毒药物的药理学目标和技术工具的使用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Technological platforms used for the screening of new antiviral drugs
One of the main characteristics of viruses is their high genetic diversity that generates viral variants with mutations associated with the resistance of antiviral drugs, which leads to therapeutic failure, increases morbidity and mortality and decreases the quality and life expectancy of infected individuals. That is why the need arises to find new alternatives that accept changes in the strongest and most effective devices. Modern pharmacological designs can be made through technological platforms, in a faster, cheaper and more effective way, which offer new promising compounds that act in host-virus binding sites. In this review, we describe the pharmacological objectives and the use of technological tools for the development of new antiviral drugs.
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